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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.
Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN. Tarragó MG, et al. Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016. Cell Metab. 2018. PMID: 29719225 Free PMC article.
Implications of the NADase CD38 in COVID pathophysiology.
Zeidler JD, Kashyap S, Hogan KA, Chini EN. Zeidler JD, et al. Physiol Rev. 2022 Jan 1;102(1):339-341. doi: 10.1152/physrev.00007.2021. Epub 2021 Sep 8. Physiol Rev. 2022. PMID: 34494892 Free PMC article. Review.
Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias.
Agorrody G, Peclat TR, Peluso G, Gonano LA, Santos L, van Schooten W, Chini CCS, Escande C, Chini EN, Contreras P. Agorrody G, et al. J Mol Cell Cardiol. 2022 May;166:11-22. doi: 10.1016/j.yjmcc.2022.01.008. Epub 2022 Feb 1. J Mol Cell Cardiol. 2022. PMID: 35114253 Free PMC article.
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions.
Zeidler JD, Hogan KA, Agorrody G, Peclat TR, Kashyap S, Kanamori KS, Gomez LS, Mazdeh DZ, Warner GM, Thompson KL, Chini CCS, Chini EN. Zeidler JD, et al. Am J Physiol Cell Physiol. 2022 Mar 1;322(3):C521-C545. doi: 10.1152/ajpcell.00451.2021. Epub 2022 Feb 9. Am J Physiol Cell Physiol. 2022. PMID: 35138178 Free PMC article. Review.
157 results