Oprea TI - Search Results

1

Unexplored therapeutic opportunities in the human genome.

Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, Ma'ayan A, Malovannaya A, Mani S, Mathias SL, McManus MT, Meehan TF, von Mering C, Muthas D, Nguyen DT, Overington JP, Papadatos G, Qin J, Reich C, Roth BL, Schürer SC, Simeonov A, Sklar LA, Southall N, Tomita S, Tudose I, Ursu O, Vidovic D, Waller A, Westergaard D, Yang JJ, Zahoránszky-Köhalmi G. Oprea TI, et al. Nat Rev Drug Discov. 2018 May;17(5):317-332. doi: 10.1038/nrd.2018.14. Epub 2018 Mar 23. Nat Rev Drug Discov. 2018. PMID: 29472638 Free PMC article. Review.

2

Flow cytometry for high-throughput, high-content screening.

Edwards BS, Oprea T, Prossnitz ER, Sklar LA. Edwards BS, et al. Curr Opin Chem Biol. 2004 Aug;8(4):392-8. doi: 10.1016/j.cbpa.2004.06.007. Curr Opin Chem Biol. 2004. PMID: 15288249 Review.

3

An automated PLS search for biologically relevant QSAR descriptors.

Olah M, Bologa C, Oprea TI. Olah M, et al. Among authors: oprea ti. J Comput Aided Mol Des. 2004 Jul-Sep;18(7-9):437-49. doi: 10.1007/s10822-004-4060-8. J Comput Aided Mol Des. 2004. PMID: 15729845

4

Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships.

Larson RS, Davis T, Bologa C, Semenuk G, Vijayan S, Li Y, Oprea T, Chigaev A, Buranda T, Wagner CR, Sklar LA. Larson RS, et al. Biochemistry. 2005 Mar 22;44(11):4322-31. doi: 10.1021/bi048187k. Biochemistry. 2005. PMID: 15766261

5

High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands.

Young SM, Bologa C, Prossnitz ER, Oprea TI, Sklar LA, Edwards BS. Young SM, et al. Among authors: oprea ti. J Biomol Screen. 2005 Jun;10(4):374-82. doi: 10.1177/1087057105274532. J Biomol Screen. 2005. PMID: 15964939

6

Post-high-throughput screening analysis: an empirical compound prioritization scheme.

Oprea TI, Bologa CG, Edwards BS, Prossnitz ER, Sklar LA. Oprea TI, et al. J Biomol Screen. 2005 Aug;10(5):419-26. doi: 10.1177/1087057104272660. J Biomol Screen. 2005. PMID: 16093551

7

Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists.

Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI. Edwards BS, et al. Among authors: oprea ti. Mol Pharmacol. 2005 Nov;68(5):1301-10. doi: 10.1124/mol.105.014068. Epub 2005 Aug 23. Mol Pharmacol. 2005. PMID: 16118363

8

Descriptor collision and confusion: toward the design of descriptors to mask chemical structures.

Bologa C, Allu TK, Olah M, Kappler MA, Oprea TI. Bologa C, et al. Among authors: oprea ti. J Comput Aided Mol Des. 2005 Sep-Oct;19(9-10):625-35. doi: 10.1007/s10822-005-9020-4. Epub 2005 Dec 2. J Comput Aided Mol Des. 2005. PMID: 16322910

9

Strategies for compound selection.

Olah MM, Bologa CG, Oprea TI. Olah MM, et al. Among authors: oprea ti. Curr Drug Discov Technol. 2004 Oct;1(3):211-20. doi: 10.2174/1570163043334965. Curr Drug Discov Technol. 2004. PMID: 16472248 Review.

10

Virtual and biomolecular screening converge on a selective agonist for GPR30.

Bologa CG, Revankar CM, Young SM, Edwards BS, Arterburn JB, Kiselyov AS, Parker MA, Tkachenko SE, Savchuck NP, Sklar LA, Oprea TI, Prossnitz ER. Bologa CG, et al. Among authors: oprea ti. Nat Chem Biol. 2006 Apr;2(4):207-12. doi: 10.1038/nchembio775. Epub 2006 Mar 5. Nat Chem Biol. 2006. PMID: 16520733

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