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Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance.
Shaffer SM, Dunagin MC, Torborg SR, Torre EA, Emert B, Krepler C, Beqiri M, Sproesser K, Brafford PA, Xiao M, Eggan E, Anastopoulos IN, Vargas-Garcia CA, Singh A, Nathanson KL, Herlyn M, Raj A. Shaffer SM, et al. Among authors: torborg sr. Nature. 2017 Jun 15;546(7658):431-435. doi: 10.1038/nature22794. Epub 2017 Jun 7. Nature. 2017. PMID: 28607484 Free PMC article.
Cellular and molecular mechanisms of plasticity in cancer.
Torborg SR, Li Z, Chan JE, Tammela T. Torborg SR, et al. Trends Cancer. 2022 Sep;8(9):735-746. doi: 10.1016/j.trecan.2022.04.007. Epub 2022 May 23. Trends Cancer. 2022. PMID: 35618573 Free PMC article. Review.
A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer.
Singhal A, Styers HC, Rub J, Li Z, Torborg SR, Kim JY, Grbovic-Huezo O, Feng H, Tarcan ZC, Sahin Ozkan H, Hallin J, Basturk O, Yaeger R, Christensen JG, Betel D, Yan Y, Chio IIC, de Stanchina E, Tammela T. Singhal A, et al. Among authors: torborg sr. Cancer Discov. 2024 Nov 1;14(11):2122-2134. doi: 10.1158/2159-8290.CD-24-0740. Cancer Discov. 2024. PMID: 38975873
Solid tumor growth depends on an intricate equilibrium of malignant cell states.
Torborg SR, Grbovic-Huezo O, Singhal A, Holm M, Wu K, Han X, Ho YJ, Haglund C, Mitchell MJ, Lowe SW, Dow LE, Pitter KL, Sanchez-Rivera FJ, Levchenko A, Tammela T. Torborg SR, et al. bioRxiv [Preprint]. 2023 Dec 30:2023.12.30.573100. doi: 10.1101/2023.12.30.573100. bioRxiv. 2023. PMID: 38234855 Free PMC article. Preprint.