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Page 1
T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G.
Spurny C, Kailayangiri S, Altvater B, Jamitzky S, Hartmann W, Wardelmann E, Ranft A, Dirksen U, Amler S, Hardes J, Fluegge M, Meltzer J, Farwick N, Greune L, Rossig C. Spurny C, et al. Among authors: farwick n. Oncotarget. 2017 Dec 22;9(5):6536-6549. doi: 10.18632/oncotarget.23815. eCollection 2018 Jan 19. Oncotarget. 2017. PMID: 29464090 Free PMC article.
Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G.
Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs AH, Wiek C, Roellecke K, Hanenberg H, Hartmann W, Wiendl H, Pankratz S, Meltzer J, Farwick N, Greune L, Fluegge M, Rossig C. Kailayangiri S, et al. Among authors: farwick n. Oncoimmunology. 2016 Oct 28;6(1):e1250050. doi: 10.1080/2162402X.2016.1250050. eCollection 2017. Oncoimmunology. 2016. PMID: 28197367 Free PMC article.
EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells.
Kailayangiri S, Altvater B, Lesch S, Balbach S, Göttlich C, Kühnemundt J, Mikesch JH, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode HN, Siebert N, Müller I, Walles H, Hartmann W, Rossig C. Kailayangiri S, et al. Among authors: farwick n. Mol Ther. 2019 May 8;27(5):933-946. doi: 10.1016/j.ymthe.2019.02.014. Epub 2019 Feb 23. Mol Ther. 2019. PMID: 30879952 Free PMC article.
HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells.
Altvater B, Kailayangiri S, Pérez Lanuza LF, Urban K, Greune L, Flügge M, Meltzer J, Farwick N, König S, Görlich D, Hartmann W, Rossig C. Altvater B, et al. Among authors: farwick n. Cancers (Basel). 2021 Jun 8;13(12):2857. doi: 10.3390/cancers13122857. Cancers (Basel). 2021. PMID: 34201079 Free PMC article.
Common Ewing sarcoma-associated antigens fail to induce natural T cell responses in both patients and healthy individuals.
Altvater B, Kailayangiri S, Theimann N, Ahlmann M, Farwick N, Chen C, Pscherer S, Neumann I, Mrachatz G, Hansmeier A, Hardes J, Gosheger G, Juergens H, Rossig C. Altvater B, et al. Among authors: farwick n. Cancer Immunol Immunother. 2014 Oct;63(10):1047-60. doi: 10.1007/s00262-014-1574-3. Epub 2014 Jun 28. Cancer Immunol Immunother. 2014. PMID: 24973179 Free PMC article.
Variable Expression of the Disialoganglioside GD2 in Breast Cancer Molecular Subtypes.
Erber R, Kailayangiri S, Huebner H, Ruebner M, Hartmann A, Häberle L, Meyer J, Völkl S, Mackensen A, Landgraf L, Geppert CI, Schulz-Wendtland R, Beckmann MW, Fasching PA, Farwick N, Rossig C, Gass P. Erber R, et al. Among authors: farwick n. Cancers (Basel). 2021 Nov 8;13(21):5577. doi: 10.3390/cancers13215577. Cancers (Basel). 2021. PMID: 34771738 Free PMC article.
Ganglioside SSEA-4 in Ewing sarcoma marks a tumor cell population with aggressive features and is a potential cell-surface immune target.
Jamitzky S, Altvater B, Krekeler C, Hoen L, Brandes C, Ebbinghaus J, Richter L, Kosel L, Ochs L, Farwick N, Urban K, Kluge L, Bücker L, Görlich D, Johnston ICD, Pfeifer R, Hartmann W, Rossig C, Kailayangiri S. Jamitzky S, et al. Among authors: farwick n. Sci Rep. 2024 May 24;14(1):11935. doi: 10.1038/s41598-024-62849-8. Sci Rep. 2024. PMID: 38789477 Free PMC article.