Ghosh AK - Search Results

1

GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants.

Delino NS, Aoki M, Hayashi H, Hattori SI, Chang SB, Takamatsu Y, Martyr CD, Das D, Ghosh AK, Mitsuya H. Delino NS, et al. Among authors: ghosh ak. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02060-17. doi: 10.1128/AAC.02060-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29463535 Free PMC article.

2

Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Ghosh AK, Thompson WJ, Holloway MK, McKee SP, Duong TT, Lee HY, Munson PM, Smith AM, Wai JM, Darke PL, et al. Ghosh AK, et al. J Med Chem. 1993 Aug 6;36(16):2300-10. doi: 10.1021/jm00068a006. J Med Chem. 1993. PMID: 8360874

3

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.

Yoshimura K, Kato R, Kavlick MF, Nguyen A, Maroun V, Maeda K, Hussain KA, Ghosh AK, Gulnik SV, Erickson JW, Mitsuya H. Yoshimura K, et al. Among authors: ghosh ak. J Virol. 2002 Feb;76(3):1349-58. doi: 10.1128/jvi.76.3.1349-1358.2002. J Virol. 2002. PMID: 11773409 Free PMC article.

4

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

Koh Y, Nakata H, Maeda K, Ogata H, Bilcer G, Devasamudram T, Kincaid JF, Boross P, Wang YF, Tie Y, Volarath P, Gaddis L, Harrison RW, Weber IT, Ghosh AK, Mitsuya H. Koh Y, et al. Among authors: ghosh ak. Antimicrob Agents Chemother. 2003 Oct;47(10):3123-9. doi: 10.1128/AAC.47.10.3123-3129.2003. Antimicrob Agents Chemother. 2003. PMID: 14506019 Free PMC article.

5

Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.

Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H. Ghosh AK, et al. J Med Chem. 2005 May 19;48(10):3576-85. doi: 10.1021/jm050019i. J Med Chem. 2005. PMID: 15887965

6

Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop.

Gatanaga H, Das D, Suzuki Y, Yeh DD, Hussain KA, Ghosh AK, Mitsuya H. Gatanaga H, et al. Among authors: ghosh ak. J Biol Chem. 2006 Jan 13;281(2):1241-50. doi: 10.1074/jbc.M505920200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16275650 Free article.

7

Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.

Ghosh AK, Schiltz G, Perali RS, Leshchenko S, Kay S, Walters DE, Koh Y, Maeda K, Mitsuya H. Ghosh AK, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1869-73. doi: 10.1016/j.bmcl.2006.01.011. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480871

8

Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.

Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H. Ghosh AK, et al. J Med Chem. 2006 Aug 24;49(17):5252-61. doi: 10.1021/jm060561m. J Med Chem. 2006. PMID: 16913714

9

Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance.

Ghosh AK, Ramu Sridhar P, Kumaragurubaran N, Koh Y, Weber IT, Mitsuya H. Ghosh AK, et al. ChemMedChem. 2006 Sep;1(9):939-50. doi: 10.1002/cmdc.200600103. ChemMedChem. 2006. PMID: 16927344 Review. No abstract available.

10

A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.

Amano M, Koh Y, Das D, Li J, Leschenko S, Wang YF, Boross PI, Weber IT, Ghosh AK, Mitsuya H. Amano M, et al. Among authors: ghosh ak. Antimicrob Agents Chemother. 2007 Jun;51(6):2143-55. doi: 10.1128/AAC.01413-06. Epub 2007 Mar 19. Antimicrob Agents Chemother. 2007. PMID: 17371811 Free PMC article.

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