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The human T-cell leukemia virus type-1 p30II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis.
Romeo M, Hutchison T, Malu A, White A, Kim J, Gardner R, Smith K, Nelson K, Bergeson R, McKee R, Harrod C, Ratner L, Lüscher B, Martinez E, Harrod R. Romeo M, et al. Among authors: harrod c, harrod r. Virology. 2018 May;518:103-115. doi: 10.1016/j.virol.2018.02.010. Epub 2018 Feb 20. Virology. 2018. PMID: 29462755 Free PMC article.
The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.
Sharma A, Awasthi S, Harrod CK, Matlock EF, Khan S, Xu L, Chan S, Yang H, Thammavaram CK, Rasor RA, Burns DK, Skiest DJ, Van Lint C, Girard AM, McGee M, Monnat RJ Jr, Harrod R. Sharma A, et al. Among authors: harrod ck, harrod r. J Biol Chem. 2007 Apr 20;282(16):12048-57. doi: 10.1074/jbc.M608104200. Epub 2007 Feb 21. J Biol Chem. 2007. PMID: 17317667 Free article.
Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30(II) accessory protein and the induction of oncogenic cellular transformation by p30(II)/c-MYC.
Romeo MM, Ko B, Kim J, Brady R, Heatley HC, He J, Harrod CK, Barnett B, Ratner L, Lairmore MD, Martinez E, Lüscher B, Robson CN, Henriksson M, Harrod R. Romeo MM, et al. Among authors: harrod ck, harrod r. Virology. 2015 Feb;476:271-288. doi: 10.1016/j.virol.2014.12.008. Epub 2015 Jan 5. Virology. 2015. PMID: 25569455 Free PMC article.
The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30II and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma.
Hutchison T, Malu A, Yapindi L, Bergeson R, Peck K, Romeo M, Harrod C, Pope J, Smitherman L, Gwinn W, Ratner L, Yates C, Harrod R. Hutchison T, et al. Among authors: harrod c, harrod r. Virology. 2018 Jul;520:39-58. doi: 10.1016/j.virol.2018.05.007. Epub 2018 May 26. Virology. 2018. PMID: 29777913 Free PMC article.
The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.
Malu A, Hutchison T, Yapindi L, Smith K, Nelson K, Bergeson R, Pope J, Romeo M, Harrod C, Ratner L, Van Lint C, Harrod R. Malu A, et al. Among authors: harrod c, harrod r. Virology. 2019 Sep;535:83-101. doi: 10.1016/j.virol.2019.07.003. Epub 2019 Jul 3. Virology. 2019. PMID: 31299491 Free PMC article.
154 results