Aye Y - Search Results

1

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.

Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. Brignole EJ, et al. Among authors: aye y. Elife. 2018 Feb 20;7:e31502. doi: 10.7554/eLife.31502. Elife. 2018. PMID: 29460780 Free PMC article.

2

Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit.

Aye Y, Stubbe J. Aye Y, et al. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9815-20. doi: 10.1073/pnas.1013274108. Epub 2011 May 31. Proc Natl Acad Sci U S A. 2011. PMID: 21628579 Free PMC article.

3

Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers.

Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Aye Y, et al. Chem Biol. 2012 Jul 27;19(7):799-805. doi: 10.1016/j.chembiol.2012.05.015. Chem Biol. 2012. PMID: 22840768 Free PMC article.

4

Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.

Aye Y, Long MJC, Stubbe J. Aye Y, et al. J Biol Chem. 2012 Oct 12;287(42):35768-35778. doi: 10.1074/jbc.M112.396911. Epub 2012 Aug 22. J Biol Chem. 2012. PMID: 22915594 Free PMC article.

5

Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase.

Fu Y, Long MJ, Rigney M, Parvez S, Blessing WA, Aye Y. Fu Y, et al. Among authors: aye y. Biochemistry. 2013 Oct 8;52(40):7050-9. doi: 10.1021/bi400781z. Epub 2013 Sep 23. Biochemistry. 2013. PMID: 24024562 Free PMC article.

6

A fluorimetric readout reporting the kinetics of nucleotide-induced human ribonucleotide reductase oligomerization.

Fu Y, Lin H, Wisitpitthaya S, Blessing WA, Aye Y. Fu Y, et al. Among authors: aye y. Chembiochem. 2014 Nov 24;15(17):2598-2604. doi: 10.1002/cbic.201402368. Epub 2014 Sep 24. Chembiochem. 2014. PMID: 25256246 Free PMC article.

7

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.

Aye Y, Li M, Long MJ, Weiss RS. Aye Y, et al. Oncogene. 2015 Apr 16;34(16):2011-21. doi: 10.1038/onc.2014.155. Epub 2014 Jun 9. Oncogene. 2015. PMID: 24909171 Review.

8

Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition.

Wisitpitthaya S, Zhao Y, Long MJ, Li M, Fletcher EA, Blessing WA, Weiss RS, Aye Y. Wisitpitthaya S, et al. Among authors: aye y. ACS Chem Biol. 2016 Jul 15;11(7):2021-32. doi: 10.1021/acschembio.6b00303. Epub 2016 May 20. ACS Chem Biol. 2016. PMID: 27159113 Free PMC article.

9

Still no Rest for the Reductases: Ribonucleotide Reductase (RNR) Structure and Function: An Update.

Long MJC, Ly P, Aye Y. Long MJC, et al. Among authors: aye y. Subcell Biochem. 2022;99:155-197. doi: 10.1007/978-3-031-00793-4_5. Subcell Biochem. 2022. PMID: 36151376 Review.

10

Z-REX uncovers a bifurcation in function of Keap1 paralogs.

Van Hall-Beauvais A, Poganik JR, Huang KT, Parvez S, Zhao Y, Lin HY, Liu X, Long MJC, Aye Y. Van Hall-Beauvais A, et al. Among authors: aye y. Elife. 2022 Oct 27;11:e83373. doi: 10.7554/eLife.83373. Elife. 2022. PMID: 36300632 Free PMC article.

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