Bigwarfe T - Search Results

1

Optimizing NBE PK/PD assays using the Gyrolab Affinity Software; conveniently within the bioanalyst's existing workflow.

Myzithras M, Bigwarfe T, Waltz E, Li H, Ahlberg J, Rybina I, Low S, Kenny CH, Miglietta J, Kroe-Barrett R. Myzithras M, et al. Among authors: bigwarfe t. Bioanalysis. 2018 Mar 1;10(6):397-406. doi: 10.4155/bio-2017-0251. Epub 2018 Feb 16. Bioanalysis. 2018. PMID: 29451404

2

Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms.

Myzithras M, Li H, Bigwarfe T, Waltz E, Gupta P, Low S, Hayes DB, MacDonnell S, Ahlberg J, Franti M, Roberts S. Myzithras M, et al. Among authors: bigwarfe t. Bioanalysis. 2016 Mar;8(6):511-8. doi: 10.4155/bio.16.17. Epub 2016 Feb 26. Bioanalysis. 2016. PMID: 26917343

3

Application of Mitra^® microsampling for pharmacokinetic bioanalysis of monoclonal antibodies in rats.

Li H, Bigwarfe T, Myzithras M, Waltz E, Ahlberg J. Li H, et al. Among authors: bigwarfe t. Bioanalysis. 2019 Jan;11(1):13-20. doi: 10.4155/bio-2018-0228. Epub 2018 Nov 21. Bioanalysis. 2019. PMID: 30461295

4

Utility of immunodeficient mouse models for characterizing the preclinical pharmacokinetics of immunogenic antibody therapeutics.

Myzithras M, Bigwarfe T, Li H, Waltz E, Ahlberg J, Giragossian C, Roberts S. Myzithras M, et al. Among authors: bigwarfe t. MAbs. 2016 Nov/Dec;8(8):1606-1611. doi: 10.1080/19420862.2016.1229721. Epub 2016 Sep 6. MAbs. 2016. PMID: 27598372 Free PMC article.

5

Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn.

Yang D, Giragossian C, Castellano S, Lasaro M, Xiao H, Saraf H, Hess Kenny C, Rybina I, Huang ZF, Ahlberg J, Bigwarfe T, Myzithras M, Waltz E, Roberts S, Kroe-Barrett R, Singh S. Yang D, et al. Among authors: bigwarfe t. MAbs. 2017 Oct;9(7):1105-1117. doi: 10.1080/19420862.2017.1359455. Epub 2017 Aug 8. MAbs. 2017. PMID: 28786732 Free PMC article.

6

Non-neutralizing antibodies increase endogenous circulating Ang1 levels.

Zheng C, Toth J, Bigwarfe T, MacDougall M, Jerath K, Bovat K, Smith J, Sun P, Hayes D, Fryer R, Singh S, Kroe-Barrett R. Zheng C, et al. Among authors: bigwarfe t. MAbs. 2018 Nov-Dec;10(8):1260-1268. doi: 10.1080/19420862.2018.1521130. Epub 2018 Nov 7. MAbs. 2018. PMID: 30199300 Free PMC article.

7

Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.

Sun P, Bartlett CS, Zheng C, Bigwarfe T, Grant JM, MacDougall M, Berger V, Kerr S, Qian HS, McHugh M, Chen H, Zhang X, Carpenter ML, Robinson HN, Miglietta J, Lamla T, Fryer RM. Sun P, et al. Among authors: bigwarfe t. J Pharmacol Exp Ther. 2022 Sep;382(3):266-276. doi: 10.1124/jpet.121.001067. Epub 2022 Jul 2. J Pharmacol Exp Ther. 2022. PMID: 35779860

8

Methods: implementation of in vitro and ex vivo phagocytosis and respiratory burst function assessments in safety testing.

Freebern WJ, Bigwarfe TJ, Price KD, Haggerty HG. Freebern WJ, et al. Among authors: bigwarfe tj. J Immunotoxicol. 2013 Jan-Mar;10(1):106-17. doi: 10.3109/1547691X.2012.736427. Epub 2012 Nov 23. J Immunotoxicol. 2013. PMID: 23173903 Free article.

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