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Page 1
Tozasertib Analogues as Inhibitors of Necroptotic Cell Death.
Hofmans S, Devisscher L, Martens S, Van Rompaey D, Goossens K, Divert T, Nerinckx W, Takahashi N, De Winter H, Van Der Veken P, Goossens V, Vandenabeele P, Augustyns K. Hofmans S, et al. J Med Chem. 2018 Mar 8;61(5):1895-1920. doi: 10.1021/acs.jmedchem.7b01449. Epub 2018 Feb 20. J Med Chem. 2018. PMID: 29437386
Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties.
Hofmans S, Vanden Berghe T, Devisscher L, Hassannia B, Lyssens S, Joossens J, Van Der Veken P, Vandenabeele P, Augustyns K. Hofmans S, et al. J Med Chem. 2016 Mar 10;59(5):2041-53. doi: 10.1021/acs.jmedchem.5b01641. Epub 2016 Feb 8. J Med Chem. 2016. PMID: 26696014
Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.
Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, Maes L, De Winter H, Van Der Veken P, Vandenabeele P, Berghe TV, Augustyns K. Devisscher L, et al. Among authors: hofmans s. J Med Chem. 2018 Nov 21;61(22):10126-10140. doi: 10.1021/acs.jmedchem.8b01299. Epub 2018 Nov 6. J Med Chem. 2018. PMID: 30354101
Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs.
Martens S, Hofmans S, Declercq W, Augustyns K, Vandenabeele P. Martens S, et al. Among authors: hofmans s. Trends Pharmacol Sci. 2020 Mar;41(3):209-224. doi: 10.1016/j.tips.2020.01.002. Epub 2020 Feb 5. Trends Pharmacol Sci. 2020. PMID: 32035657 Review.
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.
Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, Takahashi N, Bräsen JH, Lee EW, Van der Veken P, Joossens J, Augustyns K, Fulda S, Linkermann A, Song J, Vandenabeele P. Martens S, et al. Among authors: hofmans s. Cell Death Dis. 2017 Jun 29;8(6):e2904. doi: 10.1038/cddis.2017.298. Cell Death Dis. 2017. PMID: 28661484 Free PMC article.