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Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis.
Ter Haar NM, Tak T, Mokry M, Scholman RC, Meerding JM, de Jager W, Verwoerd A, Foell D, Vogl T, Roth J, Leliefeld PHC, van Loosdregt J, Koenderman L, Vastert SJ, de Roock S. Ter Haar NM, et al. Among authors: van loosdregt j. Arthritis Rheumatol. 2018 Jun;70(6):943-956. doi: 10.1002/art.40442. Epub 2018 May 7. Arthritis Rheumatol. 2018. PMID: 29426067
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells.
Wehrens EJ, Mijnheer G, Duurland CL, Klein M, Meerding J, van Loosdregt J, de Jager W, Sawitzki B, Coffer PJ, Vastert B, Prakken BJ, van Wijk F. Wehrens EJ, et al. Among authors: van loosdregt j, van wijk f. Blood. 2011 Sep 29;118(13):3538-48. doi: 10.1182/blood-2010-12-328187. Epub 2011 Aug 9. Blood. 2011. PMID: 21828127 Free article.
Canonical Wnt signaling negatively modulates regulatory T cell function.
van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ. van Loosdregt J, et al. Among authors: van boxtel r, van es jh. Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15. Immunity. 2013. PMID: 23954131 Free article.
Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.
Peeters JG, Vervoort SJ, Tan SC, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Creyghton MP, Coffer PJ, Mokry M, van Loosdregt J. Peeters JG, et al. Among authors: van loosdregt j, van wijk f. Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17. Cell Rep. 2015. PMID: 26387944 Free article.
FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.
Fleskens V, Mokry M, van der Leun AM, Huppelschoten S, Pals CE, Peeters J, Coenen S, Cardoso BA, Barata JT, van Loosdregt J, Coffer PJ. Fleskens V, et al. Among authors: van der leun am, van loosdregt j. Oncogene. 2016 Aug 4;35(31):4141-8. doi: 10.1038/onc.2015.481. Epub 2015 Dec 21. Oncogene. 2016. PMID: 26686090
Autoimmune disease-associated gene expression is reduced by BET-inhibition.
Peeters JG, Vervoort SJ, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Mokry M, van Loosdregt J. Peeters JG, et al. Among authors: van loosdregt j, van wijk f. Genom Data. 2015 Nov 7;7:14-7. doi: 10.1016/j.gdata.2015.11.004. eCollection 2016 Mar. Genom Data. 2015. PMID: 26981351 Free PMC article.
49 results