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The S4---S5 linker - gearbox of TRP channel gating.
Hofmann L, Wang H, Zheng W, Philipp SE, Hidalgo P, Cavalié A, Chen XZ, Beck A, Flockerzi V. Hofmann L, et al. Among authors: zheng w. Cell Calcium. 2017 Nov;67:156-165. doi: 10.1016/j.ceca.2017.04.002. Epub 2017 Apr 4. Cell Calcium. 2017. PMID: 28416203 Review.
Identification and characterization of hydrophobic gate residues in TRP channels.
Zheng W, Hu R, Cai R, Hofmann L, Hu Q, Fatehi M, Long W, Kong T, Tang J, Light P, Flockerzi V, Cao Y, Chen XZ. Zheng W, et al. FASEB J. 2018 Feb;32(2):639-653. doi: 10.1096/fj.201700599RR. Epub 2018 Jan 4. FASEB J. 2018. PMID: 28970257
The unconventional double-reside gating mechanism in TRP channels may have been evolved to respond especially to physiologic stimuli that trigger relatively small gate conformational changes.-Zheng, W., Hu, R., Cai, R., Hofmann, L., Hu, Q., Fatehi, M., Long, W …
The unconventional double-reside gating mechanism in TRP channels may have been evolved to respond especially to physiologic stimuli that tr …
Autoinhibition of TRPV6 Channel and Regulation by PIP2.
Cai R, Liu X, Zhang R, Hofmann L, Zheng W, Amin MR, Wang L, Hu Q, Peng JB, Michalak M, Flockerzi V, Ali DW, Chen XZ, Tang J. Cai R, et al. Among authors: zheng w. iScience. 2020 Aug 8;23(9):101444. doi: 10.1016/j.isci.2020.101444. eCollection 2020 Sep 25. iScience. 2020. PMID: 32829285 Free PMC article.
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