O'Brien EP - Search Results

1

Non-equilibrium coupling of protein structure and function to translation-elongation kinetics.

Sharma AK, O'Brien EP. Sharma AK, et al. Curr Opin Struct Biol. 2018 Apr;49:94-103. doi: 10.1016/j.sbi.2018.01.005. Epub 2018 Feb 3. Curr Opin Struct Biol. 2018. PMID: 29414517 Review.

2

Protein folding: from theory to practice.

Thirumalai D, Liu Z, O'Brien EP, Reddy G. Thirumalai D, et al. Curr Opin Struct Biol. 2013 Feb;23(1):22-9. doi: 10.1016/j.sbi.2012.11.010. Epub 2012 Dec 21. Curr Opin Struct Biol. 2013. PMID: 23266001 Review.

3

Timing is everything: unifying codon translation rates and nascent proteome behavior.

Nissley DA, O'Brien EP. Nissley DA, et al. J Am Chem Soc. 2014 Dec 31;136(52):17892-8. doi: 10.1021/ja510082j. Epub 2014 Dec 19. J Am Chem Soc. 2014. PMID: 25486504 Review.

4

Modeling the effect of codon translation rates on co-translational protein folding mechanisms of arbitrary complexity.

Caniparoli L, O'Brien EP. Caniparoli L, et al. J Chem Phys. 2015 Apr 14;142(14):145102. doi: 10.1063/1.4916914. J Chem Phys. 2015. PMID: 25877595 Free PMC article.

5

Physical Origins of Codon Positions That Strongly Influence Cotranslational Folding: A Framework for Controlling Nascent-Protein Folding.

Sharma AK, Bukau B, O'Brien EP. Sharma AK, et al. J Am Chem Soc. 2016 Feb 3;138(4):1180-95. doi: 10.1021/jacs.5b08145. Epub 2016 Jan 21. J Am Chem Soc. 2016. PMID: 26716464

6

Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding.

Nissley DA, Sharma AK, Ahmed N, Friedrich UA, Kramer G, Bukau B, O'Brien EP. Nissley DA, et al. Nat Commun. 2016 Feb 18;7:10341. doi: 10.1038/ncomms10341. Nat Commun. 2016. PMID: 26887592 Free PMC article.

7

Insights into Cotranslational Nascent Protein Behavior from Computer Simulations.

Trovato F, O'Brien EP. Trovato F, et al. Annu Rev Biophys. 2016 Jul 5;45:345-69. doi: 10.1146/annurev-biophys-070915-094153. Epub 2016 May 23. Annu Rev Biophys. 2016. PMID: 27297399 Review.

8

Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins.

Trovato F, O'Brien EP. Trovato F, et al. Biophys J. 2017 May 9;112(9):1807-1819. doi: 10.1016/j.bpj.2017.04.006. Biophys J. 2017. PMID: 28494952 Free PMC article.

9

Increasing Protein Production Rates Can Decrease the Rate at Which Functional Protein Is Produced and Their Steady-State Levels.

Sharma AK, O'Brien EP. Sharma AK, et al. J Phys Chem B. 2017 Jul 20;121(28):6775-6784. doi: 10.1021/acs.jpcb.7b01700. Epub 2017 Jul 7. J Phys Chem B. 2017. PMID: 28650169

10

Determinants of translation speed are randomly distributed across transcripts resulting in a universal scaling of protein synthesis times.

Sharma AK, Ahmed N, O'Brien EP. Sharma AK, et al. Phys Rev E. 2018 Feb;97(2-1):022409. doi: 10.1103/PhysRevE.97.022409. Phys Rev E. 2018. PMID: 29548178

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