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Activation of JAK/STAT3 restores NK-cell function and improves immune defense after brain ischemia.
Jin WN, Ducruet AF, Liu Q, Shi SX, Waters M, Zou M, Sheth KN, Gonzales R, Shi FD. Jin WN, et al. Among authors: liu q. FASEB J. 2018 May;32(5):2757-2767. doi: 10.1096/fj.201700962R. Epub 2018 Jan 8. FASEB J. 2018. PMID: 29401578 Free PMC article.
Our data suggest that brain ischemia impairs NK-cell-mediated immune defense in the periphery, at least in part through the JAK-STAT3 pathway, which can be readdressed by modulating STAT3 activation status.-Jin, W.-N., Ducruet, A. F., Liu, Q., Shi, S. X.-Y., Waters, …
Our data suggest that brain ischemia impairs NK-cell-mediated immune defense in the periphery, at least in part through the JAK-STAT3 pathwa …
Ischemic neurons recruit natural killer cells that accelerate brain infarction.
Gan Y, Liu Q, Wu W, Yin JX, Bai XF, Shen R, Wang Y, Chen J, La Cava A, Poursine-Laurent J, Yokoyama W, Shi FD. Gan Y, et al. Among authors: liu q. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2704-9. doi: 10.1073/pnas.1315943111. Epub 2014 Feb 3. Proc Natl Acad Sci U S A. 2014. PMID: 24550298 Free PMC article.
Impact of an immune modulator fingolimod on acute ischemic stroke.
Fu Y, Zhang N, Ren L, Yan Y, Sun N, Li YJ, Han W, Xue R, Liu Q, Hao J, Yu C, Shi FD. Fu Y, et al. Among authors: liu q. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18315-20. doi: 10.1073/pnas.1416166111. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489101 Free PMC article. Clinical Trial.
Immune interventions in stroke.
Fu Y, Liu Q, Anrather J, Shi FD. Fu Y, et al. Among authors: liu q. Nat Rev Neurol. 2015 Sep;11(9):524-35. doi: 10.1038/nrneurol.2015.144. Epub 2015 Aug 25. Nat Rev Neurol. 2015. PMID: 26303850 Free PMC article. Review.
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