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Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.
Zhang S, Wang J, Wang H, Fan L, Fan B, Zeng B, Tao J, Li X, Che L, Cigliano A, Ribback S, Dombrowski F, Chen B, Cong W, Wei L, Calvisi DF, Chen X. Zhang S, et al. Among authors: chen b, chen x. Am J Pathol. 2018 Apr;188(4):995-1006. doi: 10.1016/j.ajpath.2017.12.017. Epub 2018 Jan 31. Am J Pathol. 2018. PMID: 29378174 Free PMC article.
Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice.
Cigliano A, Wang C, Pilo MG, Szydlowska M, Brozzetti S, Latte G, Pes GM, Pascale RM, Seddaiu MA, Vidili G, Ribback S, Dombrowski F, Evert M, Chen X, Calvisi DF. Cigliano A, et al. Among authors: chen x. Oncotarget. 2017 Apr 7;8(33):54149-54159. doi: 10.18632/oncotarget.16927. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903330 Free PMC article.
Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development.
Liu P, Calvisi DF, Kiss A, Cigliano A, Schaff Z, Che L, Ribback S, Dombrowski F, Zhao D, Chen X. Liu P, et al. Among authors: chen x. Oncotarget. 2017 Sep 1;8(43):73433-73447. doi: 10.18632/oncotarget.20622. eCollection 2017 Sep 26. Oncotarget. 2017. PMID: 29088718 Free PMC article.
Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis.
Cigliano A, Pilo MG, Li L, Latte G, Szydlowska M, Simile MM, Paliogiannis P, Che L, Pes GM, Palmieri G, Sini MC, Cossu A, Porcu A, Vidili G, Seddaiu MA, Pascale RM, Ribback S, Dombrowski F, Chen X, Calvisi DF. Cigliano A, et al. Among authors: chen x. Oncotarget. 2017 Oct 3;8(53):90638-90650. doi: 10.18632/oncotarget.21469. eCollection 2017 Oct 31. Oncotarget. 2017. PMID: 29207593 Free PMC article.
Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.
Dong M, Liu X, Evert K, Utpatel K, Peters M, Zhang S, Xu Z, Che L, Cigliano A, Ribback S, Dombrowski F, Cossu A, Gordan J, Calvisi DF, Evert M, Liu Y, Chen X. Dong M, et al. Among authors: chen x. Cell Death Dis. 2018 Jan 18;9(2):31. doi: 10.1038/s41419-017-0183-4. Cell Death Dis. 2018. PMID: 29348467 Free PMC article.
Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.
Wang J, Dong M, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X. Wang J, et al. Among authors: chen x. Oncogene. 2018 Jun;37(24):3229-3242. doi: 10.1038/s41388-018-0188-1. Epub 2018 Mar 16. Oncogene. 2018. PMID: 29545603 Free PMC article.
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