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Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors.
Yasutake Y, Hattori SI, Tamura N, Matsuda K, Kohgo S, Maeda K, Mitsuya H. Yasutake Y, et al. Among authors: kohgo s. Biochem Biophys Res Commun. 2019 Feb 19;509(4):943-948. doi: 10.1016/j.bbrc.2019.01.026. Epub 2019 Jan 14. Biochem Biophys Res Commun. 2019. PMID: 30648556
4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.
Takamatsu Y, Tanaka Y, Kohgo S, Murakami S, Singh K, Das D, Venzon DJ, Amano M, Higashi-Kuwata N, Aoki M, Delino NS, Hayashi S, Takahashi S, Sukenaga Y, Haraguchi K, Sarafianos SG, Maeda K, Mitsuya H. Takamatsu Y, et al. Among authors: kohgo s. Hepatology. 2015 Oct;62(4):1024-36. doi: 10.1002/hep.27962. Epub 2015 Aug 25. Hepatology. 2015. PMID: 26122273 Free PMC article.
CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.
Higashi-Kuwata N, Hayashi S, Das D, Kohgo S, Murakami S, Hattori SI, Imoto S, Venzon DJ, Singh K, Sarafianos SG, Tanaka Y, Mitsuya H. Higashi-Kuwata N, et al. Among authors: kohgo s. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02143-18. doi: 10.1128/AAC.02143-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30670420 Free PMC article.
Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.
Onitsuka K, Tokuda R, Kuwata-Higashi N, Kumamoto H, Aoki M, Amano M, Kohgo S, Das D, Haraguchi K, Mitsuya H, Imoto S. Onitsuka K, et al. Among authors: kohgo s. Nucleosides Nucleotides Nucleic Acids. 2020;39(4):518-529. doi: 10.1080/15257770.2019.1664749. Epub 2019 Sep 12. Nucleosides Nucleotides Nucleic Acids. 2020. PMID: 31514570 Free PMC article.
Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.
Hattori S, Ide K, Nakata H, Harada H, Suzu S, Ashida N, Kohgo S, Hayakawa H, Mitsuya H, Okada S. Hattori S, et al. Among authors: kohgo s. Antimicrob Agents Chemother. 2009 Sep;53(9):3887-93. doi: 10.1128/AAC.00270-09. Epub 2009 Jun 22. Antimicrob Agents Chemother. 2009. PMID: 19546363 Free PMC article.
Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.
Imoto S, Kohgo S, Tokuda R, Kumamoto H, Aoki M, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K. Imoto S, et al. Among authors: kohgo s. Nucleosides Nucleotides Nucleic Acids. 2015;34(8):590-602. doi: 10.1080/15257770.2015.1037456. Nucleosides Nucleotides Nucleic Acids. 2015. PMID: 26167667 Free PMC article.
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