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Page 1
Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.
Fleming KA, Ericson MD, Freeman KT, Adank DN, Lunzer MM, Wilber SL, Haskell-Luevano C. Fleming KA, et al. ACS Chem Neurosci. 2018 May 16;9(5):1141-1151. doi: 10.1021/acschemneuro.7b00495. Epub 2018 Feb 13. ACS Chem Neurosci. 2018. PMID: 29363944 Free PMC article.
Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.
Ericson MD, Freeman KT, Schnell SM, Fleming KA, Haskell-Luevano C. Ericson MD, et al. Among authors: fleming ka. J Med Chem. 2017 Oct 12;60(19):8103-8114. doi: 10.1021/acs.jmedchem.7b00856. Epub 2017 Oct 4. J Med Chem. 2017. PMID: 28813605 Free PMC article.
Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles.
Ericson MD, Koerperich ZM, Freeman KT, Fleming KA, Haskell-Luevano C. Ericson MD, et al. Among authors: fleming ka. ACS Chem Neurosci. 2018 Dec 19;9(12):3015-3023. doi: 10.1021/acschemneuro.8b00218. Epub 2018 Jul 20. ACS Chem Neurosci. 2018. PMID: 29924583 Free PMC article.
Comparative Intracerebroventricular and Intrathecal Administration of a Nanomolar Macrocyclic Melanocortin Receptor Agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) Decreases Food Intake in Mice.
Adank DN, Lunzer MM, Ericson MD, Koeperich ZM, Wilber SL, Fleming KA, Haskell-Luevano C. Adank DN, et al. Among authors: fleming ka. ACS Chem Neurosci. 2020 Oct 7;11(19):3051-3063. doi: 10.1021/acschemneuro.0c00409. Epub 2020 Sep 10. ACS Chem Neurosci. 2020. PMID: 32822157 Free PMC article.
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.
Ericson MD, Lensing CJ, Fleming KA, Schlasner KN, Doering SR, Haskell-Luevano C. Ericson MD, et al. Among authors: fleming ka. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2414-2435. doi: 10.1016/j.bbadis.2017.03.020. Epub 2017 Mar 29. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28363699 Free PMC article. Review.
Improved pathology reporting in NAFLD/NASH for clinical trials.
Langford CR, Goldinger MH, Treanor D, McGenity C, Dillman JR, Allende DS, Goldin R, Brunt EM, Zatloukal K, Denk H, Fleming KA. Langford CR, et al. Among authors: fleming ka. J Clin Pathol. 2022 Feb;75(2):73-75. doi: 10.1136/jclinpath-2021-207967. Epub 2021 Nov 9. J Clin Pathol. 2022. PMID: 34753791 Free PMC article. No abstract available.
174 results