Meerman JHN - Search Results

1

IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer.

Zhang Y, Wester L, He J, Geiger T, Moerkens M, Siddappa R, Helmijr JA, Timmermans MM, Look MP, van Deurzen CHM, Martens JWM, Pont C, de Graauw M, Danen EHJ, Berns EMJJ, Meerman JHN, Jansen MPHM, van de Water B. Zhang Y, et al. Among authors: meerman jhn. Oncogene. 2018 Apr;37(14):1869-1884. doi: 10.1038/s41388-017-0027-9. Epub 2018 Jan 22. Oncogene. 2018. PMID: 29353882

2

A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer.

Wester L, Venneker S, Hazenoot M, Pont C, Koedoot E, Timmermans AM, Martens JWM, Jansen MPHM, Kockx CEM, van IJcken WFJ, Meerman JHN, Zhang Y, van de Water B. Wester L, et al. Among authors: meerman jhn. Biochem Pharmacol. 2022 Oct;204:115233. doi: 10.1016/j.bcp.2022.115233. Epub 2022 Aug 28. Biochem Pharmacol. 2022. PMID: 36041543 Free article.

3

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.

Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B. Zhang Y, et al. Breast Cancer Res. 2011 May 19;13(3):R52. doi: 10.1186/bcr2883. Breast Cancer Res. 2011. PMID: 21595894 Free PMC article.

4

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation.

Moerkens M, Zhang Y, Wester L, van de Water B, Meerman JH. Moerkens M, et al. BMC Cancer. 2014 Apr 23;14:283. doi: 10.1186/1471-2407-14-283. BMC Cancer. 2014. PMID: 24758408 Free PMC article.

5

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells.

Benedetti G, Fredriksson L, Herpers B, Meerman J, van de Water B, de Graauw M. Benedetti G, et al. Biochem Pharmacol. 2013 Jan 15;85(2):274-86. doi: 10.1016/j.bcp.2012.10.012. Epub 2012 Oct 24. Biochem Pharmacol. 2013. PMID: 23103562

6

The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch.

Benedetti G, Fokkelman M, Yan K, Fredriksson L, Herpers B, Meerman J, van de Water B, de Graauw M. Benedetti G, et al. Mol Pharmacol. 2013 Jul;84(1):128-38. doi: 10.1124/mol.112.084053. Epub 2013 Apr 26. Mol Pharmacol. 2013. PMID: 23625948

7

Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells.

Verissimo CS, Molenaar JJ, Meerman J, Puigvert JC, Lamers F, Koster J, Danen EH, van de Water B, Versteeg R, Fitzsimons CP, Vreugdenhil E. Verissimo CS, et al. Endocr Relat Cancer. 2010 Apr 21;17(2):399-414. doi: 10.1677/ERC-09-0301. Print 2010 Jun. Endocr Relat Cancer. 2010. PMID: 20228126

8

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.

Carreras Puigvert J, von Stechow L, Siddappa R, Pines A, Bahjat M, Haazen LC, Olsen JV, Vrieling H, Meerman JH, Mullenders LH, van de Water B, Danen EH. Carreras Puigvert J, et al. Sci Signal. 2013 Jan 22;6(259):ra5. doi: 10.1126/scisignal.2003208. Sci Signal. 2013. PMID: 23354688

9

β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer.

Truong HH, Xiong J, Ghotra VP, Nirmala E, Haazen L, Le Dévédec SE, Balcioğlu HE, He S, Snaar-Jagalska BE, Vreugdenhil E, Meerman JH, van de Water B, Danen EH. Truong HH, et al. Sci Signal. 2014 Feb 11;7(312):ra15. doi: 10.1126/scisignal.2004751. Sci Signal. 2014. PMID: 24518294

10

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500

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