Abou-Gharbia M - Search Results

1

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.

Bryant KG, Chae YC, Martinez RL, Gordon JC, Elokely KM, Kossenkov AV, Grant S, Childers WE, Abou-Gharbia M, Altieri DC. Bryant KG, et al. Oncotarget. 2017 Dec 11;8(68):112184-112198. doi: 10.18632/oncotarget.23097. eCollection 2017 Dec 22. Oncotarget. 2017. PMID: 29348817 Free PMC article.

2

Discovery of innovative therapeutics: today's realities and tomorrow's vision. 1. Criticisms faced by the pharmaceutical industry.

Abou-Gharbia M, Childers WE. Abou-Gharbia M, et al. J Med Chem. 2013 Jul 25;56(14):5659-72. doi: 10.1021/jm400330j. Epub 2013 Apr 29. J Med Chem. 2013. PMID: 23557017

3

Discovery of innovative therapeutics: today's realities and tomorrow's vision. 2. Pharma's challenges and their commitment to innovation.

Abou-Gharbia M, Childers WE. Abou-Gharbia M, et al. J Med Chem. 2014 Jul 10;57(13):5525-53. doi: 10.1021/jm401564r. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24428137

4

Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors.

Al-Ashmawy AAK, Ragab FA, Elokely KM, Anwar MM, Perez-Leal O, Rico MC, Gordon J, Bichenkov E, Mateo G, Kassem EMM, Hegazy GH, Abou-Gharbia M, Childers W. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122. doi: 10.1016/j.bmcl.2017.05.044. Epub 2017 May 15. Bioorg Med Chem Lett. 2017. PMID: 28571824

5

The Resurrection of Phenotypic Drug Discovery.

Childers WE, Elokely KM, Abou-Gharbia M. Childers WE, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1820-1828. doi: 10.1021/acsmedchemlett.0c00006. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062159 Free PMC article.

6

Discovery and SAR of Novel Disubstituted Quinazolines as Dual PI3Kalpha/mTOR Inhibitors Targeting Breast Cancer.

Al-Ashmawy AAK, Elokely KM, Perez-Leal O, Rico M, Gordon J, Mateo G, Omar AM, Abou-Gharbia M, Childers WE Jr. Al-Ashmawy AAK, et al. ACS Med Chem Lett. 2020 Oct 12;11(11):2156-2164. doi: 10.1021/acsmedchemlett.0c00289. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214824 Free PMC article.

7

"I'll Be Back": The Resurrection of Dezocine.

Childers WE, Abou-Gharbia MA. Childers WE, et al. ACS Med Chem Lett. 2021 May 19;12(6):961-968. doi: 10.1021/acsmedchemlett.1c00233. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34141081 Free PMC article.

8

Discovery of Novel Small-Molecule Inhibitors of SARS-CoV-2 Main Protease as Potential Leads for COVID-19 Treatment.

Manandhar A, Srinivasulu V, Hamad M, Tarazi H, Omar H, Colussi DJ, Gordon J, Childers W, Klein ML, Al-Tel TH, Abou-Gharbia M, Elokely KM. Manandhar A, et al. J Chem Inf Model. 2021 Sep 27;61(9):4745-4757. doi: 10.1021/acs.jcim.1c00684. Epub 2021 Aug 17. J Chem Inf Model. 2021. PMID: 34403259

9

Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.

El-Awady R, Saleh E, Hamoudi R, Ramadan WS, Mazitschek R, Nael MA, Elokely KM, Abou-Gharbia M, Childers WE, Srinivasulu V, Aloum L, Menon V, Al-Tel TH. El-Awady R, et al. Bioorg Med Chem. 2021 Jul 15;42:116251. doi: 10.1016/j.bmc.2021.116251. Epub 2021 Jun 8. Bioorg Med Chem. 2021. PMID: 34116381

10

A novel assay platform for the detection of translation modulators of spermidine/spermine acetyltransferase.

Perez-Leal O, Abou-Gharbia M, Gordon J, Childers WE, Merali S. Perez-Leal O, et al. Curr Pharm Des. 2014;20(2):245-52. doi: 10.2174/13816128113199990035. Curr Pharm Des. 2014. PMID: 23701549 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

78 results

Search Page

Filters