He L - Search Results

1

Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

He L, Pei H, Zhang C, Shao M, Li D, Tang M, Wang T, Chen X, Xiang M, Chen L. He L, et al. Eur J Med Chem. 2018 Feb 10;145:96-112. doi: 10.1016/j.ejmech.2017.12.079. Epub 2017 Dec 28. Eur J Med Chem. 2018. PMID: 29324347

2

Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations.

Li S, Wang W, Tang H, Chen K, Yang J, He L, Ye H, Peng A, Chen L. Li S, et al. Among authors: he l. J Chromatogr A. 2014 May 30;1344:51-8. doi: 10.1016/j.chroma.2014.04.004. Epub 2014 Apr 12. J Chromatogr A. 2014. PMID: 24767948

3

Synthesis and biological evaluation of 5-nitropyrimidine-2,4-dione analogues as inhibitors of nitric oxide and iNOS activity.

Ma L, He L, Lei L, Liang X, Lei K, Zhang R, Yang Z, Chen L. Ma L, et al. Among authors: he l. Chem Biol Drug Des. 2015 Mar;85(3):296-9. doi: 10.1111/cbdd.12386. Epub 2014 Sep 5. Chem Biol Drug Des. 2015. PMID: 24985766

4

Synthesis and biological evaluation of 3-methyl-5-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives for the treatment of diet-induced obesity.

Sang Y, Pei H, Ma L, Huang L, Xie C, Chen J, Liang X, Ran Y, Wang G, Yang Z, Cao D, He L, Wu Y, He L, Zhu J, Lan J, Chen L. Sang Y, et al. Among authors: he l. Chem Pharm Bull (Tokyo). 2014;62(9):883-91. doi: 10.1248/cpb.c14-00258. Chem Pharm Bull (Tokyo). 2014. PMID: 25177017 Free article.

5

Discovery of a Potent 9-Deazaxanthine-based Agent for the Treatment of Obesity-Related Non-alcoholic Fatty Liver Disease.

Chen J, Ma L, Huang L, Xie C, Pei H, He L, Fu S, Chen L. Chen J, et al. Among authors: he l. Chem Biol Drug Des. 2015 Jul;86(1):66-79. doi: 10.1111/cbdd.12429. Epub 2015 May 14. Chem Biol Drug Des. 2015. PMID: 25215862

6

Synthesis and biological evaluation of tert-butyl-5-methylpyrimidin-piperazine derivatives as anti-obesity agents.

Chen J, Pu Y, Pei H, He L, Fu S, Chen L. Chen J, et al. Among authors: he l. Arch Pharm (Weinheim). 2014 Dec;347(12):908-22. doi: 10.1002/ardp.201400227. Epub 2014 Sep 15. Arch Pharm (Weinheim). 2014. PMID: 25220533

7

Synthesis and lipid-lowering evaluation of 3-methyl-1H-purine-2,6-dione derivatives as potent and orally available anti-obesity agents.

He L, Pei H, Ma L, Pu Y, Chen J, Liu Z, Ran Y, Lei L, Fu S, Tang M, Peng A, Long C, Chen L. He L, et al. Eur J Med Chem. 2014 Nov 24;87:595-610. doi: 10.1016/j.ejmech.2014.09.094. Epub 2014 Sep 30. Eur J Med Chem. 2014. PMID: 25299682

8

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.

Ma L, Pei H, Lei L, He L, Chen J, Liang X, Peng A, Ye H, Xiang M, Chen L. Ma L, et al. Among authors: he l. Eur J Med Chem. 2015 Mar 6;92:178-90. doi: 10.1016/j.ejmech.2014.12.036. Epub 2014 Dec 26. Eur J Med Chem. 2015. PMID: 25555141

9

Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.

He J, Ma L, Wei Z, Zhu J, Peng F, Shao M, Lei L, He L, Tang M, He L, Wu Y, Chen L. He J, et al. Among authors: he l. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2429-33. doi: 10.1016/j.bmcl.2015.03.087. Epub 2015 Apr 3. Bioorg Med Chem Lett. 2015. PMID: 25881822

10

Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.

Wang T, Yang Z, Zhang Y, Yan W, Wang F, He L, Zhou Y, Chen L. Wang T, et al. Among authors: he l. Eur J Med Chem. 2017 Mar 31;129:275-286. doi: 10.1016/j.ejmech.2017.02.020. Epub 2017 Feb 9. Eur J Med Chem. 2017. PMID: 28231524

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