Chen X - Search Results

1

Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

He L, Pei H, Zhang C, Shao M, Li D, Tang M, Wang T, Chen X, Xiang M, Chen L. He L, et al. Among authors: chen l, chen x. Eur J Med Chem. 2018 Feb 10;145:96-112. doi: 10.1016/j.ejmech.2017.12.079. Epub 2017 Dec 28. Eur J Med Chem. 2018. PMID: 29324347

2

Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis.

Pei H, He L, Shao M, Yang Z, Ran Y, Li D, Zhou Y, Tang M, Wang T, Gong Y, Chen X, Yang S, Xiang M, Chen L. Pei H, et al. Among authors: chen l, chen x. Sci Rep. 2018 Mar 27;8(1):5273. doi: 10.1038/s41598-018-23569-y. Sci Rep. 2018. PMID: 29588471 Free PMC article.

3

The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin.

Yang J, Yan W, Yu Y, Wang Y, Yang T, Xue L, Yuan X, Long C, Liu Z, Chen X, Hu M, Zheng L, Qiu Q, Pei H, Li D, Wang F, Bai P, Wen J, Ye H, Chen L. Yang J, et al. Among authors: chen l, chen x. J Biol Chem. 2018 Jun 15;293(24):9461-9472. doi: 10.1074/jbc.RA117.001658. Epub 2018 Apr 24. J Biol Chem. 2018. PMID: 29691282 Free PMC article.

4

Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.

Yang Z, Wang T, Wang F, Niu T, Liu Z, Chen X, Long C, Tang M, Cao D, Wang X, Xiang W, Yi Y, Ma L, You J, Chen L. Yang Z, et al. Among authors: chen l, chen x. J Med Chem. 2016 Feb 25;59(4):1455-70. doi: 10.1021/acs.jmedchem.5b01342. Epub 2015 Oct 13. J Med Chem. 2016. PMID: 26443078

5

Pharmacological effects of the water fraction of key components in the traditional Chinese prescription Mai Tong Fang on 3T3-L1 adipocytes and ob/ob diabetic mice.

Ma L, Huang L, Pei H, Liu Z, Xie C, Lei L, Chen X, Ye H, Peng A, Chen L. Ma L, et al. Among authors: chen l, chen x. Molecules. 2014 Sep 16;19(9):14687-98. doi: 10.3390/molecules190914687. Molecules. 2014. PMID: 25230123 Free PMC article.

6

Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping.

Wang Y, Chen Z, Dai M, Sun P, Wang C, Gao Y, Zhao H, Zeng W, Shen L, Mao W, Wang T, Hu G, Li J, Chen S, Long C, Chen X, Liu J, Zhang Y. Wang Y, et al. Among authors: chen z, chen s, chen x. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2420-2423. doi: 10.1016/j.bmcl.2017.04.014. Epub 2017 Apr 5. Bioorg Med Chem Lett. 2017. PMID: 28433531

7

α-Lipoic acid stabilized DTX/IR780 micelles for photoacoustic/fluorescence imaging guided photothermal therapy/chemotherapy of breast cancer.

Li W , Peng J , Yang Q , Chen L , Zhang L , Chen X , Qian Z . Li W , et al. Among authors: chen l, chen x. Biomater Sci. 2018 May 1;6(5):1201-1216. doi: 10.1039/c8bm00096d. Biomater Sci. 2018. PMID: 29578215

8

A simple method to improve the stability of docetaxel micelles.

Zhang L, Tan L, Chen L, Chen X, Long C, Peng J, Qian Z. Zhang L, et al. Among authors: chen l, chen x. Sci Rep. 2016 Nov 11;6:36957. doi: 10.1038/srep36957. Sci Rep. 2016. PMID: 27833135 Free PMC article.

9

Flavonoids from the stems of Millettia pachyloba Drake mediate cytotoxic activity through apoptosis and autophagy in cancer cells.

Yan W, Yang J, Tang H, Xue L, Chen K, Wang L, Zhao M, Tang M, Peng A, Long C, Chen X, Ye H, Chen L. Yan W, et al. Among authors: chen k, chen l, chen x. J Adv Res. 2019 Jun 21;20:117-127. doi: 10.1016/j.jare.2019.06.002. eCollection 2019 Nov. J Adv Res. 2019. PMID: 31338224 Free PMC article.

10

Biodegradable Interlayer-Crosslinked Polymer Micelles with Reduction Sensitivity for Non-Small Cell Lung Cancer Therapy.

Wang Z, Wen J, Liu H, Zheng L, Luo H, Liu Z, Chen X, Wang F, Li D, Pei H, Li W, Chen L. Wang Z, et al. Among authors: chen l, chen x. J Biomed Nanotechnol. 2018 Jul 1;14(7):1225-1238. doi: 10.1166/jbn.2018.2538. J Biomed Nanotechnol. 2018. PMID: 29944097

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