Spyracopoulos L - Search Results

1

RYBP Is a K63-Ubiquitin-Chain-Binding Protein that Inhibits Homologous Recombination Repair.

Ali MAM, Strickfaden H, Lee BL, Spyracopoulos L, Hendzel MJ. Ali MAM, et al. Among authors: spyracopoulos l. Cell Rep. 2018 Jan 9;22(2):383-395. doi: 10.1016/j.celrep.2017.12.047. Cell Rep. 2018. PMID: 29320735 Free article.

2

A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p.

Horvat NK, Armstrong H, Lee BL, Mercier R, Wolmarans A, Knowles J, Spyracopoulos L, LaPointe P. Horvat NK, et al. Among authors: spyracopoulos l. J Mol Biol. 2014 Jun 12;426(12):2379-92. doi: 10.1016/j.jmb.2014.04.002. Epub 2014 Apr 12. J Mol Biol. 2014. PMID: 24726918

3

Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.

Hodge CD, Edwards RA, Markin CJ, McDonald D, Pulvino M, Huen MS, Zhao J, Spyracopoulos L, Hendzel MJ, Glover JN. Hodge CD, et al. Among authors: spyracopoulos l. ACS Chem Biol. 2015 Jul 17;10(7):1718-28. doi: 10.1021/acschembio.5b00222. Epub 2015 May 1. ACS Chem Biol. 2015. PMID: 25909880 Free PMC article.

4

The Mechanism of Hsp90 ATPase Stimulation by Aha1.

Wolmarans A, Lee B, Spyracopoulos L, LaPointe P. Wolmarans A, et al. Among authors: spyracopoulos l. Sci Rep. 2016 Sep 12;6:33179. doi: 10.1038/srep33179. Sci Rep. 2016. PMID: 27615124 Free PMC article.

5

Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.

Lee BL, Singh A, Mark Glover JN, Hendzel MJ, Spyracopoulos L. Lee BL, et al. Among authors: spyracopoulos l. J Mol Biol. 2017 Nov 10;429(22):3409-3429. doi: 10.1016/j.jmb.2017.05.029. Epub 2017 Jun 3. J Mol Biol. 2017. PMID: 28587922 Free PMC article. Review.

6

Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.

Rout MK, Lee BL, Lin A, Xiao W, Spyracopoulos L. Rout MK, et al. Among authors: spyracopoulos l. Sci Rep. 2018 May 3;8(1):7002. doi: 10.1038/s41598-018-25476-8. Sci Rep. 2018. PMID: 29725124 Free PMC article.

7

The Hsp90 Chaperone: ¹H and ¹⁹F Dynamic Nuclear Magnetic Resonance Spectroscopy Reveals a Perfect Enzyme.

Lee BL, Rashid S, Wajda B, Wolmarans A, LaPointe P, Spyracopoulos L. Lee BL, et al. Among authors: spyracopoulos l. Biochemistry. 2019 Apr 9;58(14):1869-1877. doi: 10.1021/acs.biochem.9b00144. Epub 2019 Mar 22. Biochemistry. 2019. PMID: 30869872

8

Side-Chain Dynamics of the Trifluoroacetone Cysteine Derivative Characterized by ¹⁹F NMR Relaxation and Molecular Dynamics Simulations.

Rashid S, Lee BL, Wajda B, Spyracopoulos L. Rashid S, et al. Among authors: spyracopoulos l. J Phys Chem B. 2019 May 2;123(17):3665-3671. doi: 10.1021/acs.jpcb.9b01741. Epub 2019 Apr 22. J Phys Chem B. 2019. PMID: 30973726

9

Nucleotide Binding and Active Site Gate Dynamics for the Hsp90 Chaperone ATPase Domain from Benchtop and High Field ¹⁹F NMR Spectroscopy.

Rashid S, Lee BL, Wajda B, Spyracopoulos L. Rashid S, et al. Among authors: spyracopoulos l. J Phys Chem B. 2020 Apr 16;124(15):2984-2993. doi: 10.1021/acs.jpcb.0c00626. Epub 2020 Apr 3. J Phys Chem B. 2020. PMID: 32212608

10

Molecular basis for impaired DNA damage response function associated with the RAP80 ΔE81 defect.

Anamika, Markin CJ, Rout MK, Spyracopoulos L. Anamika, et al. Among authors: spyracopoulos l. J Biol Chem. 2014 May 2;289(18):12852-62. doi: 10.1074/jbc.M113.538280. Epub 2014 Mar 13. J Biol Chem. 2014. PMID: 24627472 Free PMC article.

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