Cowan S - Search Results

1

Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay.

Shaw J, Leveridge M, Norling C, Karén J, Molina DM, O'Neill D, Dowling JE, Davey P, Cowan S, Dabrowski M, Main M, Gianni D. Shaw J, et al. Among authors: cowan s. Sci Rep. 2018 Jan 9;8(1):163. doi: 10.1038/s41598-017-18650-x. Sci Rep. 2018. PMID: 29317749 Free PMC article.

2

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

McCoull W, Cheung T, Anderson E, Barton P, Burgess J, Byth K, Cao Q, Castaldi MP, Chen H, Chiarparin E, Carbajo RJ, Code E, Cowan S, Davey PR, Ferguson AD, Fillery S, Fuller NO, Gao N, Hargreaves D, Howard MR, Hu J, Kawatkar A, Kemmitt PD, Leo E, Molina DM, O'Connell N, Petteruti P, Rasmusson T, Raubo P, Rawlins PB, Ricchiuto P, Robb GR, Schenone M, Waring MJ, Zinda M, Fawell S, Wilson DM. McCoull W, et al. Among authors: cowan s. ACS Chem Biol. 2018 Nov 16;13(11):3131-3141. doi: 10.1021/acschembio.8b00698. Epub 2018 Oct 17. ACS Chem Biol. 2018. PMID: 30335946

3

Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.

Frederickson M, Callaghan O, Chessari G, Congreve M, Cowan SR, Matthews JE, McMenamin R, Smith DM, Vinković M, Wallis NG. Frederickson M, et al. J Med Chem. 2008 Jan 24;51(2):183-6. doi: 10.1021/jm701359z. Epub 2007 Dec 29. J Med Chem. 2008. PMID: 18163548

4

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

Murray CW, Carr MG, Callaghan O, Chessari G, Congreve M, Cowan S, Coyle JE, Downham R, Figueroa E, Frederickson M, Graham B, McMenamin R, O'Brien MA, Patel S, Phillips TR, Williams G, Woodhead AJ, Woolford AJ. Murray CW, et al. Among authors: cowan s. J Med Chem. 2010 Aug 26;53(16):5942-55. doi: 10.1021/jm100059d. J Med Chem. 2010. PMID: 20718493

5

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.

Congreve M, Aharony D, Albert J, Callaghan O, Campbell J, Carr RA, Chessari G, Cowan S, Edwards PD, Frederickson M, McMenamin R, Murray CW, Patel S, Wallis N. Congreve M, et al. Among authors: cowan s. J Med Chem. 2007 Mar 22;50(6):1124-32. doi: 10.1021/jm061197u. Epub 2007 Feb 22. J Med Chem. 2007. PMID: 17315857

6

X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.

St Denis JD, Chessari G, Cleasby A, Cons BD, Cowan S, Dalton SE, East C, Murray CW, O'Reilly M, Peakman T, Rapti M, Stow JL. St Denis JD, et al. Among authors: cowan s. J Med Chem. 2022 Sep 22;65(18):12319-12333. doi: 10.1021/acs.jmedchem.2c01044. Epub 2022 Sep 13. J Med Chem. 2022. PMID: 36101934

7

Trends in the Epidemiology of Deep Vein Thrombosis and Pulmonary Embolism in Patients Undergoing Surgery.

Cowan S, Ghayyad K, Conlon MJ, Naik M, Zeini I, Hawks M, Ahmed A, Kachooei AR. Cowan S, et al. Cureus. 2024 Dec 1;16(12):e74925. doi: 10.7759/cureus.74925. eCollection 2024 Dec. Cureus. 2024. PMID: 39742181 Free PMC article.

8

Maternal and neonatal outcomes following resuscitative hysterotomy for out of hospital cardiac arrest: a systematic review.

Leech C, Nutbeam T, Chu J, Knight M, Hinshaw K, Appleyard TL, Cowan S, Couper K, Yeung J. Leech C, et al. Among authors: cowan s. Resuscitation. 2024 Dec 28:110479. doi: 10.1016/j.resuscitation.2024.110479. Online ahead of print. Resuscitation. 2024. PMID: 39736393 Review.

9

Metrics for Perioperative Exercise in Patients Undergoing Lung Cancer Resection: A Systematic Review.

Stumm TW, Mina S, Okusanya O, Cowan S, Evans NR, Grenda TR. Stumm TW, et al. Among authors: cowan s. Clin Lung Cancer. 2025 Jan;26(1):e33-e40. doi: 10.1016/j.cllc.2024.11.006. Epub 2024 Nov 16. Clin Lung Cancer. 2025. PMID: 39638661 Review.

10

Understanding barriers and facilitators to lifestyle management in people with polycystic ovary syndrome: A mixed method systematic review.

McGowan M, Garad R, Wadhwani G, Torkel S, Rao V, Maunder A, Osei-Safo EK, Moran LJ, Cowan S. McGowan M, et al. Among authors: cowan s. Obes Rev. 2025 Feb;26(2):e13854. doi: 10.1111/obr.13854. Epub 2024 Oct 27. Obes Rev. 2025. PMID: 39462252 Review.

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