Zha X - Search Results

1

Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening.

Zou F, Pusch S, Hua J, Ma T, Yang L, Zhu Q, Xu Y, Gu Y, von Deimling A, Zha X. Zou F, et al. Among authors: zha x. Bioorg Med Chem Lett. 2018 Feb 1;28(3):388-393. doi: 10.1016/j.bmcl.2017.12.030. Epub 2017 Dec 13. Bioorg Med Chem Lett. 2018. PMID: 29290542

2

Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.

Zhou C, Kang D, Xu Y, Zhang L, Zha X. Zhou C, et al. Among authors: zha x. Chem Biol Drug Des. 2015 Jun;85(6):659-71. doi: 10.1111/cbdd.12461. Epub 2014 Dec 22. Chem Biol Drug Des. 2015. PMID: 25346381

3

Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.

Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M. Zha X, et al. J Med Chem. 2016 Jan 14;59(1):114-31. doi: 10.1021/acs.jmedchem.5b01119. Epub 2015 Dec 29. J Med Chem. 2016. PMID: 26632651 Free article.

4

Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors.

Xi J, Xu S, Wu L, Ma T, Liu R, Liu YC, Deng D, Gu Y, Zhou J, Lan F, Zha X. Xi J, et al. Among authors: zha x. Bioorg Chem. 2017 Jun;72:182-189. doi: 10.1016/j.bioorg.2017.04.006. Epub 2017 Apr 13. Bioorg Chem. 2017. PMID: 28460360

5

Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.

Ma T, Zou F, Pusch S, Yang L, Zhu Q, Xu Y, Gu Y, von Deimling A, Zha X. Ma T, et al. Among authors: zha x. Bioorg Med Chem. 2017 Dec 15;25(24):6379-6387. doi: 10.1016/j.bmc.2017.10.009. Epub 2017 Oct 13. Bioorg Med Chem. 2017. PMID: 29089260

6

Design, synthesis and biological activity of 4-(4-benzyloxy)phenoxypiperidines as selective and reversible LSD1 inhibitors.

Xi J, Xu S, Zhang L, Bi X, Ren Y, Liu YC, Gu Y, Xu Y, Lan F, Zha X. Xi J, et al. Among authors: zha x. Bioorg Chem. 2018 Aug;78:7-16. doi: 10.1016/j.bioorg.2018.02.016. Epub 2018 Feb 16. Bioorg Chem. 2018. PMID: 29524666

7

Recent advances in inhibitors of sirtuin1/2: an update and perspective.

Zhou Z, Ma T, Zhu Q, Xu Y, Zha X. Zhou Z, et al. Among authors: zha x. Future Med Chem. 2018 Apr 1;10(8):907-934. doi: 10.4155/fmc-2017-0207. Epub 2018 Apr 12. Future Med Chem. 2018. PMID: 29642711 Review.

8

Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective.

Ma T, Zou F, Pusch S, Xu Y, von Deimling A, Zha X. Ma T, et al. Among authors: zha x. J Med Chem. 2018 Oct 25;61(20):8981-9003. doi: 10.1021/acs.jmedchem.8b00159. Epub 2018 Jun 18. J Med Chem. 2018. PMID: 29847930 Review.

9

Novel Opioid Receptor Agonists with Reduced Morphine-like Side Effects.

Zhu L, Cui Z, Zhu Q, Zha X, Xu Y. Zhu L, et al. Among authors: zha x. Mini Rev Med Chem. 2018;18(19):1603-1610. doi: 10.2174/1389557518666180716124336. Mini Rev Med Chem. 2018. PMID: 30009707 Review.

10

Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia.

Xu S, Zhou C, Liu R, Zhu Q, Xu Y, Lan F, Zha X. Xu S, et al. Among authors: zha x. Bioorg Med Chem. 2018 Sep 15;26(17):4871-4880. doi: 10.1016/j.bmc.2018.08.026. Epub 2018 Aug 22. Bioorg Med Chem. 2018. PMID: 30153955

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