Frayling TM - Search Results

1

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.

Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee S, Lincoln SE, Trubetskoy V, DePristo M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Mazur A, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Zöllner S, Curran JE, Peralta J, Akolkar B, Bell GI, Burtt NP, Cox NJ, Florez JC, Hanis CL, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Dupuis J, Nicolae DL, Lehman D, Park T, Won S, Sladek R, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Abecasis GR, Blangero J. Jun G, et al. Among authors: frayling tm. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):379-384. doi: 10.1073/pnas.1705859115. Epub 2017 Dec 26. Proc Natl Acad Sci U S A. 2018. PMID: 29279374 Free PMC article.

2

Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K.

Beards F, Frayling T, Bulman M, Horikawa Y, Allen L, Appleton M, Bell GI, Ellard S, Hattersley AT. Beards F, et al. Diabetes. 1998 Jul;47(7):1152-4. doi: 10.2337/diabetes.47.7.1152. Diabetes. 1998. PMID: 9648841 Review. No abstract available.

3

Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.

Bingham C, Ellard S, Allen L, Bulman M, Shepherd M, Frayling T, Berry PJ, Clark PM, Lindner T, Bell GI, Ryffel GU, Nicholls AJ, Hattersley AT. Bingham C, et al. Kidney Int. 2000 Mar;57(3):898-907. doi: 10.1046/j.1523-1755.2000.057003898.x. Kidney Int. 2000. PMID: 10720943 Free article.

4

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.

Wiltshire S, Frayling TM, Hattersley AT, Hitman GA, Walker M, Levy JC, O'Rahilly S, Groves CJ, Menzel S, Cardon LR, McCarthy MI. Wiltshire S, et al. Among authors: frayling tm. Am J Hum Genet. 2002 Feb;70(2):543-6. doi: 10.1086/338760. Epub 2001 Dec 20. Am J Hum Genet. 2002. PMID: 11753821 Free PMC article.

5

Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.

Minton JA, Hattersley AT, Owen K, McCarthy MI, Walker M, Latif F, Barrett T, Frayling TM. Minton JA, et al. Among authors: frayling tm. Diabetes. 2002 Apr;51(4):1287-90. doi: 10.2337/diabetes.51.4.1287. Diabetes. 2002. PMID: 11916957

6

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.

Haddad L, Evans JC, Gharani N, Robertson C, Rush K, Wiltshire S, Frayling TM, Wilkin TJ, Demaine A, Millward A, Hattersley AT, Conway G, Cox NJ, Bell GI, Franks S, McCarthy MI. Haddad L, et al. Among authors: frayling tm. J Clin Endocrinol Metab. 2002 Jun;87(6):2606-10. doi: 10.1210/jcem.87.6.8608. J Clin Endocrinol Metab. 2002. PMID: 12050223

7

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM. Gloyn AL, et al. Among authors: frayling tm. Diabetes. 2003 Feb;52(2):568-72. doi: 10.2337/diabetes.52.2.568. Diabetes. 2003. PMID: 12540637

8

Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.

Mitchell SM, Weedon MN, Owen KR, Shields B, Wilkins-Wall B, Walker M, McCarthy MI, Frayling TM, Hattersley AT. Mitchell SM, et al. Among authors: frayling tm. Diabetes. 2003 May;52(5):1276-9. doi: 10.2337/diabetes.52.5.1276. Diabetes. 2003. PMID: 12716764

9

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI. Groves CJ, et al. Among authors: frayling tm. Diabetes. 2003 May;52(5):1300-5. doi: 10.2337/diabetes.52.5.1300. Diabetes. 2003. PMID: 12716770

10

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.

Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, Sampson M, Groves CJ, Menzel S, McCarthy MI, Hattersley AT. Frayling TM, et al. Diabetes. 2003 Jul;52(7):1857-63. doi: 10.2337/diabetes.52.7.1857. Diabetes. 2003. PMID: 12829657

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