Bomke J - Search Results

1

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding.

Amaral M, Kokh DB, Bomke J, Wegener A, Buchstaller HP, Eggenweiler HM, Matias P, Sirrenberg C, Wade RC, Frech M. Amaral M, et al. Among authors: bomke j. Nat Commun. 2017 Dec 22;8(1):2276. doi: 10.1038/s41467-017-02258-w. Nat Commun. 2017. PMID: 29273709 Free PMC article.

2

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations.

Kokh DB, Amaral M, Bomke J, Grädler U, Musil D, Buchstaller HP, Dreyer MK, Frech M, Lowinski M, Vallee F, Bianciotto M, Rak A, Wade RC. Kokh DB, et al. Among authors: bomke j. J Chem Theory Comput. 2018 Jul 10;14(7):3859-3869. doi: 10.1021/acs.jctc.8b00230. Epub 2018 Jun 4. J Chem Theory Comput. 2018. PMID: 29768913 Free article.

3

Functional analysis of Hsp70 inhibitors.

Schlecht R, Scholz SR, Dahmen H, Wegener A, Sirrenberg C, Musil D, Bomke J, Eggenweiler HM, Mayer MP, Bukau B. Schlecht R, et al. Among authors: bomke j. PLoS One. 2013 Nov 12;8(11):e78443. doi: 10.1371/journal.pone.0078443. eCollection 2013. PLoS One. 2013. PMID: 24265689 Free PMC article.

4

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Berger BT, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, Schröder M, Neil R, Wang J, Navratilova I, Bomke J, Elkins JM, Müller S, Frech M, Wade RC, Knapp S. Berger BT, et al. Among authors: bomke j. Cell Chem Biol. 2021 May 20;28(5):686-698.e7. doi: 10.1016/j.chembiol.2021.01.003. Epub 2021 Jan 25. Cell Chem Biol. 2021. PMID: 33497606 Free article.

5

In-depth biophysical analysis of interactions between therapeutic antibodies and the extracellular domain of the epidermal growth factor receptor.

Alvarenga ML, Kikhney J, Hannewald J, Metzger AU, Steffens KJ, Bomke J, Krah A, Wegener A. Alvarenga ML, et al. Among authors: bomke j. Anal Biochem. 2012 Feb 1;421(1):138-51. doi: 10.1016/j.ab.2011.10.039. Epub 2011 Oct 28. Anal Biochem. 2012. PMID: 22085444

6

Sequential assignment and secondary structure of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen.

Maurer T, Bomke J, Frech M, Rysiok T, Kalbitzer HB. Maurer T, et al. Among authors: bomke j. J Biomol NMR. 2001 Sep;21(1):77-8. doi: 10.1023/a:1011946217030. J Biomol NMR. 2001. PMID: 11693575 No abstract available.

7

Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1.

Lemercier G, Fernandez-Montalvan A, Shaw JP, Kugelstadt D, Bomke J, Domostoj M, Schwarz MK, Scheer A, Kappes B, Leroy D. Lemercier G, et al. Among authors: bomke j. Biochemistry. 2009 Jul 14;48(27):6379-89. doi: 10.1021/bi9005122. Biochemistry. 2009. PMID: 19507895

8

MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.

Heinrich T, Schwarz D, Petersson C, Gunera J, Garg S, Schneider R, Keil M, Grimmeisen L, Unzue Lopez A, Albers L, Schlesiger S, Gambardella A, Bomke J, Carswell E, Schilke H, Diehl P, Doerfel B, Musil D, Trivier E, Broome R, Marshall S, Balsiger A, Friedrich E, Lemos AR, Santos SP, Sousa PMF, Freire F, Bandeiras TM, Bortoluzzi A, Wienke D. Heinrich T, et al. Among authors: bomke j. J Med Chem. 2024 Dec 20. doi: 10.1021/acs.jmedchem.4c01949. Online ahead of print. J Med Chem. 2024. PMID: 39704449

9

Impact of the Smarter Safer Homes Solution on Quality of Life and Health Outcomes in Older People Living in Their Own Homes: Randomized Controlled Trial.

Lu W, Silvera-Tawil D, Yoon HJ, Higgins L, Zhang Q, Karunanithi M, Bomke J, Byrnes J, Hewitt J, Smallbon V, Freyne J, Prabhu D, Varnfield M. Lu W, et al. Among authors: bomke j. J Med Internet Res. 2024 Nov 11. doi: 10.2196/59921. Online ahead of print. J Med Internet Res. 2024. PMID: 39608020 Free article.

10

Novel Multicomponent Digital Care Assistant and Support Program for People After Stroke or Transient Ischaemic Attack: A Pilot Feasibility Study.

Allan LP, Silvera-Tawil D, Cameron J, Li J, Varnfield M, Smallbon V, Bomke J, Olaiya MT, Lannin NA, Cadilhac DA. Allan LP, et al. Among authors: bomke j. Sensors (Basel). 2024 Nov 13;24(22):7253. doi: 10.3390/s24227253. Sensors (Basel). 2024. PMID: 39599030 Free PMC article.

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