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Page 1
Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling".
Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F, Lisanti MP. Pavlides S, et al. Aging (Albany NY). 2010 Apr;2(4):185-99. doi: 10.18632/aging.100134. Aging (Albany NY). 2010. PMID: 20442453 Free PMC article.
Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.
Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Pavlides S, et al. Cell Cycle. 2010 Jun 1;9(11):2201-19. doi: 10.4161/cc.9.11.11848. Cell Cycle. 2010. PMID: 20519932 Free article.
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
Migneco G, Whitaker-Menezes D, Chiavarina B, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Flomenberg N, Tsirigos A, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Migneco G, et al. Cell Cycle. 2010 Jun 15;9(12):2412-22. doi: 10.4161/cc.9.12.11989. Epub 2010 Jun 15. Cell Cycle. 2010. PMID: 20562527 Free article.
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F. Martinez-Outschoorn UE, et al. Cell Cycle. 2010 Sep 1;9(17):3515-33. doi: 10.4161/cc.9.17.12928. Epub 2010 Sep 9. Cell Cycle. 2010. PMID: 20855962 Free PMC article.
HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.
Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, Tanowitz HB, Casimiro MC, Wang C, Pestell RG, Grieshaber P, Caro J, Sotgia F, Lisanti MP. Chiavarina B, et al. Cell Cycle. 2010 Sep 1;9(17):3534-51. doi: 10.4161/cc.9.17.12908. Epub 2010 Sep 4. Cell Cycle. 2010. PMID: 20864819 Free PMC article.
Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.
Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP. Whitaker-Menezes D, et al. Cell Cycle. 2011 Jun 1;10(11):1772-83. doi: 10.4161/cc.10.11.15659. Epub 2011 Jun 1. Cell Cycle. 2011. PMID: 21558814 Free PMC article.
141 results