Curcumin Inhibits Protein Kinase Cα Activity by Binding to Its C1 Domain.
Pany S, You Y, Das J.
Pany S, et al.
Biochemistry. 2016 Nov 15;55(45):6327-6336. doi: 10.1021/acs.biochem.6b00932. Epub 2016 Nov 2.
Biochemistry. 2016.
PMID: 27776404
Free PMC article.
We have recently shown that curcumin selectively inhibits PKCalpha, but not PKCepsilon, in CHO-K1 cells [Pany, S. (2016) Biochemistry 55, 2135-2143]. To understand which domain(s) of PKCalpha is responsible for curcumin binding and inhibitory activity, we mad …
We have recently shown that curcumin selectively inhibits PKCalpha, but not PKCepsilon, in CHO-K1 cells [Pany, S. (2016) Bioch …