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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.
van Vliet VJE, Huynh N, Palà J, Patel A, Singer A, Slater C, Chung J, van Huizen M, Teyra J, Miersch S, Luu GK, Ye W, Sharma N, Ganaie SS, Russell R, Chen C, Maynard M, Amarasinghe GK, Mark BL, Kikkert M, Sidhu SS. van Vliet VJE, et al. Among authors: chen c. PLoS Pathog. 2022 Dec 22;18(12):e1011065. doi: 10.1371/journal.ppat.1011065. eCollection 2022 Dec. PLoS Pathog. 2022. PMID: 36548304 Free PMC article.
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants.
Labriola JM, Miersch S, Chen G, Chen C, Pavlenco A, Saberianfar R, Caccuri F, Zani A, Sharma N, Feng A, Leung DW, Caruso A, Novelli G, Amarasinghe GK, Sidhu SS. Labriola JM, et al. Among authors: chen c, chen g. ACS Chem Biol. 2022 Jul 15;17(7):1978-1988. doi: 10.1021/acschembio.2c00411. Epub 2022 Jun 22. ACS Chem Biol. 2022. PMID: 35731947
Biosynthesis of bromoform by Curvularia fungi provides a natural pathway to mitigate enteric methane emissions from ruminants.
Loan T, Karpe A, Babaei S, Denman S, Chen C, Joust M, Lam K, Hussain D, Vibhakaran SP, Callaghan M, Chaudhury A, Paco K, Tomkins N, Yang T, Payne S, Ayliffe M, Luo M. Loan T, et al. Among authors: chen c. Biotechnol Rep (Amst). 2025 Jan 14;45:e00876. doi: 10.1016/j.btre.2025.e00876. eCollection 2025 Mar. Biotechnol Rep (Amst). 2025. PMID: 39906407 Free PMC article.
Radish Seed Exerts Anti-Diabetic and Obesity-Reducing Effects in Mice by Promoting the Activation of Uncoupling Protein 1 and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-α.
Wang YC, Hsu YA, Lin SC, Chien LS, Chen JJY, Wu MY, Lin HJ, Chen CS, Huang YQ, Tsai YC, Wan L. Wang YC, et al. Among authors: chen cs. J Evid Based Integr Med. 2025 Jan-Dec;30:2515690X251316760. doi: 10.1177/2515690X251316760. J Evid Based Integr Med. 2025. PMID: 39905916
Direct-acting antiviral therapy for patients with HCV-related hepatocellular carcinoma: A nationwide cohort study.
Lee SW, Yang SS, Tsai PC, Huang CF, Chen CY, Hung CH, Chen CH, Tai CM, Cheng PN, Kuo HT, Tseng KC, Mo LR, Lo CC, Huang YH, Lin HC, Lee PL, Bair MJ, Chang TS, Lin CY, Wang SJ, Hsieh TY, Yang TH, Peng CY, Yang CC, Chong LW, Huang CW, Lin CW, Chu CH, Tsai MC, Kao JH, Liu CJ, Chuang WL, Lee TY, Yu ML; TACR investigators. Lee SW, et al. Among authors: chen ch, chen cy. Clin Mol Hepatol. 2025 Feb 5. doi: 10.3350/cmh.2024.1015. Online ahead of print. Clin Mol Hepatol. 2025. PMID: 39905837
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