Kowlessur D - Search Results

1

The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papain.

Brocklehurst K, O'Driscoll M, Kowlessur D, Phillips IR, Templeton W, Thomas EW, Topham CM, Wharton CW. Brocklehurst K, et al. Among authors: kowlessur d. Biochem J. 1989 Jan 1;257(1):309-10. doi: 10.1042/bj2570309. Biochem J. 1989. PMID: 2920023 Free PMC article. No abstract available.

2

Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis.

Topham CM, Salih E, Frazao C, Kowlessur D, Overington JP, Thomas M, Brocklehurst SM, Patel M, Thomas EW, Brocklehurst K. Topham CM, et al. Among authors: kowlessur d. Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):79-92. doi: 10.1042/bj2800079. Biochem J. 1991. PMID: 1741760 Free PMC article.

3

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.

Templeton W, Kowlessur D, Thomas EW, Topham CM, Brocklehurst K. Templeton W, et al. Among authors: kowlessur d. Biochem J. 1990 Mar 15;266(3):645-51. doi: 10.1042/bj2660645. Biochem J. 1990. PMID: 2327953 Free PMC article.

4

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides.

Kowlessur D, Thomas EW, Topham CM, Templeton W, Brocklehurst K. Kowlessur D, et al. Biochem J. 1990 Mar 15;266(3):653-60. doi: 10.1042/bj2660653. Biochem J. 1990. PMID: 2327954 Free PMC article.

5

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain.

Kowlessur D, O'Driscoll M, Topham CM, Templeton W, Thomas EW, Brocklehurst K. Kowlessur D, et al. Biochem J. 1989 Apr 15;259(2):443-52. doi: 10.1042/bj2590443. Biochem J. 1989. PMID: 2719659 Free PMC article.

6

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain.

Kowlessur D, Topham CM, Thomas EW, O'Driscoll M, Templeton W, Brocklehurst K. Kowlessur D, et al. Biochem J. 1989 Mar 15;258(3):755-64. doi: 10.1042/bj2580755. Biochem J. 1989. PMID: 2730566 Free PMC article.

7

Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe studies targeted on the catalytic-site thiol group and its immediate microenvironment.

Salih E, Malthouse JP, Kowlessur D, Jarvis M, O'Driscoll M, Brocklehurst K. Salih E, et al. Among authors: kowlessur d. Biochem J. 1987 Oct 1;247(1):181-93. doi: 10.1042/bj2470181. Biochem J. 1987. PMID: 2825655 Free PMC article.

8

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics.

Brocklehurst K, Brocklehurst SM, Kowlessur D, O'Driscoll M, Patel G, Salih E, Templeton W, Thomas E, Topham CM, Willenbrock F. Brocklehurst K, et al. Among authors: kowlessur d. Biochem J. 1988 Dec 1;256(2):543-58. doi: 10.1042/bj2560543. Biochem J. 1988. PMID: 3223929 Free PMC article.

9

Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papain.

Thomas MP, Topham CM, Kowlessur D, Mellor GW, Thomas EW, Whitford D, Brocklehurst K. Thomas MP, et al. Among authors: kowlessur d. Biochem J. 1994 Jun 15;300 ( Pt 3)(Pt 3):805-20. doi: 10.1042/bj3000805. Biochem J. 1994. PMID: 8010964 Free PMC article.

10

Three-dimensional structure and thiol reactivity characteristics of chymopapain M (papaya proteinase IV).

Topham CM, Overington J, Thomas M, Kowlessur D, Thomas EW, Brocklehurst K. Topham CM, et al. Among authors: kowlessur d. Biochem Soc Trans. 1990 Oct;18(5):934-5. doi: 10.1042/bst0180934. Biochem Soc Trans. 1990. PMID: 2083746 No abstract available.

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