Dömling A - Search Results

1

Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?

Konstantinidou M, Zarganes-Tzitzikas T, Magiera-Mularz K, Holak TA, Dömling A. Konstantinidou M, et al. Among authors: domling a. Angew Chem Int Ed Engl. 2018 Apr 23;57(18):4840-4848. doi: 10.1002/anie.201710407. Epub 2018 Feb 23. Angew Chem Int Ed Engl. 2018. PMID: 29178534 Free PMC article. Review.

2

Robust NMR screening for lead compounds using tryptophan-containing proteins.

Bista M, Kowalska K, Janczyk W, Dömling A, Holak TA. Bista M, et al. Among authors: domling a. J Am Chem Soc. 2009 Jun 10;131(22):7500-1. doi: 10.1021/ja901863h. J Am Chem Soc. 2009. PMID: 19422216

3

Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists.

Srivastava S, Beck B, Wang W, Czarna A, Holak TA, Dömling A. Srivastava S, et al. Among authors: domling a. J Comb Chem. 2009 Jul-Aug;11(4):631-9. doi: 10.1021/cc9000218. J Comb Chem. 2009. PMID: 19548636 Free PMC article.

4

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

Popowicz GM, Czarna A, Wolf S, Wang K, Wang W, Dömling A, Holak TA. Popowicz GM, et al. Among authors: domling a. Cell Cycle. 2010 Mar 15;9(6):1104-11. doi: 10.4161/cc.9.6.10956. Epub 2010 Mar 15. Cell Cycle. 2010. PMID: 20237429

5

1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.

Huang Y, Wolf S, Bista M, Meireles L, Camacho C, Holak TA, Dömling A. Huang Y, et al. Among authors: domling a. Chem Biol Drug Des. 2010 Aug;76(2):116-29. doi: 10.1111/j.1747-0285.2010.00989.x. Epub 2010 May 18. Chem Biol Drug Des. 2010. PMID: 20492448 Free PMC article.

6

Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

Czarna A, Beck B, Srivastava S, Popowicz GM, Wolf S, Huang Y, Bista M, Holak TA, Dömling A. Czarna A, et al. Among authors: domling a. Angew Chem Int Ed Engl. 2010 Jul 19;49(31):5352-6. doi: 10.1002/anie.201001343. Angew Chem Int Ed Engl. 2010. PMID: 20575124 Free PMC article. No abstract available.

7

The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious.

Popowicz GM, Dömling A, Holak TA. Popowicz GM, et al. Among authors: domling a. Angew Chem Int Ed Engl. 2011 Mar 14;50(12):2680-8. doi: 10.1002/anie.201003863. Epub 2011 Feb 21. Angew Chem Int Ed Engl. 2011. PMID: 21341346 Free PMC article. Review.

8

Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists.

Huang Y, Wolf S, Koes D, Popowicz GM, Camacho CJ, Holak TA, Dömling A. Huang Y, et al. Among authors: domling a. ChemMedChem. 2012 Jan 2;7(1):49-52. doi: 10.1002/cmdc.201100428. Epub 2011 Sep 27. ChemMedChem. 2012. PMID: 21954050 Free PMC article. No abstract available.

9

Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists.

Koes D, Khoury K, Huang Y, Wang W, Bista M, Popowicz GM, Wolf S, Holak TA, Dömling A, Camacho CJ. Koes D, et al. Among authors: domling a. PLoS One. 2012;7(3):e32839. doi: 10.1371/journal.pone.0032839. Epub 2012 Mar 12. PLoS One. 2012. PMID: 22427896 Free PMC article.

10

Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2.

Wang W, Cao H, Wolf S, Camacho-Horvitz MS, Holak TA, Dömling A. Wang W, et al. Among authors: domling a. Bioorg Med Chem. 2013 Jul 15;21(14):3982-95. doi: 10.1016/j.bmc.2012.06.020. Epub 2012 Jun 20. Bioorg Med Chem. 2013. PMID: 22789708 Free PMC article.

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