Cravatt BF - Search Results

1

Global profiling of lysine reactivity and ligandability in the human proteome.

Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF. Hacker SM, et al. Among authors: cravatt bf. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31. Nat Chem. 2017. PMID: 29168484 Free PMC article.

2

Profiling the specific reactivity of the proteome with non-directed activity-based probes.

Adam GC, Cravatt BF, Sorensen EJ. Adam GC, et al. Among authors: cravatt bf. Chem Biol. 2001 Jan;8(1):81-95. doi: 10.1016/s1074-5521(00)90060-7. Chem Biol. 2001. PMID: 11182321

3

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype.

Adam GC, Sorensen EJ, Cravatt BF. Adam GC, et al. Among authors: cravatt bf. Nat Biotechnol. 2002 Aug;20(8):805-9. doi: 10.1038/nbt714. Epub 2002 Jul 1. Nat Biotechnol. 2002. PMID: 12091914

4

Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase.

McKinney MK, Cravatt BF. McKinney MK, et al. Among authors: cravatt bf. J Biol Chem. 2003 Sep 26;278(39):37393-9. doi: 10.1074/jbc.M303922200. Epub 2003 May 6. J Biol Chem. 2003. PMID: 12734197 Free article.

5

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.

Leung D, Hardouin C, Boger DL, Cravatt BF. Leung D, et al. Among authors: cravatt bf. Nat Biotechnol. 2003 Jun;21(6):687-91. doi: 10.1038/nbt826. Epub 2003 May 12. Nat Biotechnol. 2003. PMID: 12740587

6

Discovering disease-associated enzymes by proteome reactivity profiling.

Barglow KT, Cravatt BF. Barglow KT, et al. Among authors: cravatt bf. Chem Biol. 2004 Nov;11(11):1523-31. doi: 10.1016/j.chembiol.2004.08.023. Chem Biol. 2004. PMID: 15556003

7

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.

Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. Leung D, et al. Among authors: cravatt bf. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1423-8. doi: 10.1016/j.bmcl.2004.12.085. Bioorg Med Chem Lett. 2005. PMID: 15713400

8

A streamlined platform for high-content functional proteomics of primary human specimens.

Jessani N, Niessen S, Wei BQ, Nicolau M, Humphrey M, Ji Y, Han W, Noh DY, Yates JR 3rd, Jeffrey SS, Cravatt BF. Jessani N, et al. Among authors: cravatt bf. Nat Methods. 2005 Sep;2(9):691-7. doi: 10.1038/nmeth778. Nat Methods. 2005. PMID: 16118640

9

Live chemical reports from the cell surface.

Cravatt BF. Cravatt BF. Chem Biol. 2005 Sep;12(9):954-6; discussion 999-1006. doi: 10.1016/j.chembiol.2005.09.001. Chem Biol. 2005. PMID: 16183017

10

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.

Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF. Evans MJ, et al. Among authors: cravatt bf. Nat Biotechnol. 2005 Oct;23(10):1303-7. doi: 10.1038/nbt1149. Epub 2005 Oct 2. Nat Biotechnol. 2005. PMID: 16200062

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