Cheng P - Search Results

1

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.

De Santo C, Booth S, Vardon A, Cousins A, Tubb V, Perry T, Noyvert B, Beggs A, Ng M, Halsey C, Kearns P, Cheng P, Mussai F. De Santo C, et al. Among authors: cheng p. Int J Cancer. 2018 Apr 1;142(7):1490-1502. doi: 10.1002/ijc.31170. Epub 2017 Dec 26. Int J Cancer. 2018. PMID: 29168171 Free PMC article.

2

Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest.

Lam TL, Wong GK, Chong HC, Cheng PN, Choi SC, Chow TL, Kwok SY, Poon RT, Wheatley DN, Lo WH, Leung YC. Lam TL, et al. Among authors: cheng pn. Cancer Lett. 2009 May 8;277(1):91-100. doi: 10.1016/j.canlet.2008.11.031. Epub 2009 Jan 12. Cancer Lett. 2009. PMID: 19138817

3

Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.

Lam TL, Wong GK, Chow HY, Chong HC, Chow TL, Kwok SY, Cheng PN, Wheatley DN, Lo WH, Leung YC. Lam TL, et al. Pigment Cell Melanoma Res. 2011 Apr;24(2):366-76. doi: 10.1111/j.1755-148X.2010.00798.x. Epub 2010 Dec 6. Pigment Cell Melanoma Res. 2011. PMID: 21029397

4

Anti-tumor efficacy of a recombinant human arginase in human hepatocellular carcinoma.

Chow AK, Ng L, Sing Li H, Cheng CW, Lam CS, Yau TC, Cheng PN, Fan ST, Poon RT, Pang RW. Chow AK, et al. Among authors: cheng pn, cheng cw. Curr Cancer Drug Targets. 2012 Nov 1;12(9):1233-43. doi: 10.2174/156800912803988002. Curr Cancer Drug Targets. 2012. PMID: 22873218 Review.

5

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target.

Mussai F, Egan S, Higginbotham-Jones J, Perry T, Beggs A, Odintsova E, Loke J, Pratt G, U KP, Lo A, Ng M, Kearns P, Cheng P, De Santo C. Mussai F, et al. Among authors: cheng p. Blood. 2015 Apr 9;125(15):2386-96. doi: 10.1182/blood-2014-09-600643. Epub 2015 Feb 20. Blood. 2015. PMID: 25710880 Free PMC article.

6

Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies.

Vardon A, Dandapani M, Cheng D, Cheng P, De Santo C, Mussai F. Vardon A, et al. Among authors: cheng p, cheng d. Oncotarget. 2017 Jun 29;8(38):63506-63517. doi: 10.18632/oncotarget.18843. eCollection 2017 Sep 8. Oncotarget. 2017. PMID: 28969007 Free PMC article.

7

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma.

De Santo C, Cheng P, Beggs A, Egan S, Bessudo A, Mussai F. De Santo C, et al. Among authors: cheng p. J Hematol Oncol. 2018 May 18;11(1):68. doi: 10.1186/s13045-018-0612-6. J Hematol Oncol. 2018. PMID: 29776373 Free PMC article. Clinical Trial.

8

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.

Mussai F, Wheat R, Sarrou E, Booth S, Stavrou V, Fultang L, Perry T, Kearns P, Cheng P, Keeshan K, Craddock C, De Santo C. Mussai F, et al. Among authors: cheng p. Int J Cancer. 2019 Oct 15;145(8):2201-2208. doi: 10.1002/ijc.32028. Epub 2019 Jan 11. Int J Cancer. 2019. PMID: 30485425 Free PMC article. Clinical Trial.

9

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.

Fultang L, Gamble LD, Gneo L, Berry AM, Egan SA, De Bie F, Yogev O, Eden GL, Booth S, Brownhill S, Vardon A, McConville CM, Cheng PN, Norris MD, Etchevers HC, Murray J, Ziegler DS, Chesler L, Schmidt R, Burchill SA, Haber M, De Santo C, Mussai F. Fultang L, et al. Cancer Res. 2019 Feb 1;79(3):611-624. doi: 10.1158/0008-5472.CAN-18-2139. Epub 2018 Dec 13. Cancer Res. 2019. PMID: 30545920 Free PMC article.

10

A phase II clinical study on the efficacy and predictive biomarker of pegylated recombinant arginase on hepatocellular carcinoma.

Chan SL, Cheng PNM, Liu AM, Chan LL, Li L, Chu CM, Chong CCN, Lau YM, Yeo W, Ng KKC, Yu SCH, Mok TSK, Chan AWH. Chan SL, et al. Invest New Drugs. 2021 Oct;39(5):1375-1382. doi: 10.1007/s10637-021-01111-8. Epub 2021 Apr 15. Invest New Drugs. 2021. PMID: 33856599 Free PMC article. Clinical Trial.

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