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Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.
Fedele M, Pentimalli F, Baldassarre G, Battista S, Klein-Szanto AJ, Kenyon L, Visone R, De Martino I, Ciarmiello A, Arra C, Viglietto G, Croce CM, Fusco A. Fedele M, et al. Among authors: arra c. Oncogene. 2005 May 12;24(21):3427-35. doi: 10.1038/sj.onc.1208501. Oncogene. 2005. PMID: 15735694
A mouse model demonstrates a multigenic origin of congenital hypothyroidism.
Amendola E, De Luca P, Macchia PE, Terracciano D, Rosica A, Chiappetta G, Kimura S, Mansouri A, Affuso A, Arra C, Macchia V, Di Lauro R, De Felice M. Amendola E, et al. Among authors: arra c. Endocrinology. 2005 Dec;146(12):5038-47. doi: 10.1210/en.2005-0882. Epub 2005 Sep 8. Endocrinology. 2005. PMID: 16150900
Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.
Fedele M, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJ, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce CM, Fusco A. Fedele M, et al. Among authors: arra c. Cancer Res. 2006 Mar 1;66(5):2536-43. doi: 10.1158/0008-5472.CAN-05-1889. Cancer Res. 2006. Retraction in: Cancer Res. 2018 Dec 15;78(24):6908. doi: 10.1158/0008-5472.CAN-18-3457. PMID: 16510570 Free article. Retracted.
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
Fedele M, Visone R, De Martino I, Troncone G, Palmieri D, Battista S, Ciarmiello A, Pallante P, Arra C, Melillo RM, Helin K, Croce CM, Fusco A. Fedele M, et al. Among authors: arra c. Cancer Cell. 2006 Jun;9(6):459-71. doi: 10.1016/j.ccr.2006.04.024. Cancer Cell. 2006. PMID: 16766265 Free article.
The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.
Caraglia M, Marra M, Viscomi C, D'Alessandro AM, Budillon A, Meo G, Arra C, Barbieri A, Rapp UR, Baldi A, Tassone P, Venuta S, Abbruzzese A, Tagliaferri P. Caraglia M, et al. Among authors: arra c. Int J Cancer. 2007 Nov 15;121(10):2317-30. doi: 10.1002/ijc.22964. Int J Cancer. 2007. PMID: 17657738
171 results