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Defining sepsis on the wards: results of a multi-centre point-prevalence study comparing two sepsis definitions.
Szakmany T, Pugh R, Kopczynska M, Lundin RM, Sharif B, Morgan P, Ellis G, Abreu J, Kulikouskaya S, Bashir K, Galloway L, Al-Hassan H, Grother T, McNulty P, Seal ST, Cains A, Vreugdenhil M, Abdimalik M, Dennehey N, Evans G, Whitaker J, Beasant E, Hall C, Lazarou M, Vanderpump CV, Harding K, Duffy L, Guerrier Sadler A, Keeling R, Banks C, Ng SWY, Heng SY, Thomas D, Puw EW, Otahal I, Battle C, Minik O, Lyons RA, Hall JE; Welsh Digital Data Collection Platform collaborators. Szakmany T, et al. Among authors: lazarou m. Anaesthesia. 2018 Feb;73(2):195-204. doi: 10.1111/anae.14062. Epub 2017 Nov 17. Anaesthesia. 2018. PMID: 29150856 Free article.
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards.
Kopczynska M, Unwin H, Pugh RJ, Sharif B, Chandy T, Davies DJ, Shield ME, Purchase DE, Tilley SC, Poacher A, Oliva L, Willis S, Ray IE, Hui JNC, Payne BC, Wardle EF, Andrew F, Chan HMP, Barrington J, Hale J, Hawkins J, Nicholas JK, Wirt LE, Thomas LH, Walker M, Pan MP, Ray T, Asim UH, Maidman V, Atiyah Z, Nasser ZM, Tan ZX, Tan LJP, Szakmany T; Welsh Digital Data Collection Platform collaborators. Kopczynska M, et al. Sci Rep. 2021 Aug 10;11(1):16222. doi: 10.1038/s41598-021-95648-6. Sci Rep. 2021. PMID: 34376757 Free PMC article.
Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery.
Adriaenssens E, Schaar S, Cook ASI, Stuke JFM, Sawa-Makarska J, Nguyen TN, Ren X, Schuschnig M, Romanov J, Khuu G, Lazarou M, Hummer G, Hurley JH, Martens S. Adriaenssens E, et al. Among authors: lazarou m. bioRxiv [Preprint]. 2024 Aug 28:2024.08.28.609967. doi: 10.1101/2024.08.28.609967. bioRxiv. 2024. PMID: 39253418 Free PMC article. Preprint.
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4.
Nguyen-Dien GT, Townsend B, Kulkarni PG, Kozul KL, Ooi SS, Eldershaw DN, Weeratunga S, Liu M, Jones MJ, Millard SS, Ng DC, Pagano M, Bonfim-Melo A, Schneider T, Komander D, Lazarou M, Collins BM, Pagan JK. Nguyen-Dien GT, et al. Among authors: lazarou m. EMBO Rep. 2024 Aug;25(8):3324-3347. doi: 10.1038/s44319-024-00181-y. Epub 2024 Jul 11. EMBO Rep. 2024. PMID: 38992176 Free PMC article.
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD.
Adriaenssens E, Nguyen TN, Sawa-Makarska J, Khuu G, Schuschnig M, Shoebridge S, Skulsuppaisarn M, Watts EM, Csalyi KD, Padman BS, Lazarou M, Martens S. Adriaenssens E, et al. Among authors: lazarou m. Nat Struct Mol Biol. 2024 Nov;31(11):1717-1731. doi: 10.1038/s41594-024-01338-y. Epub 2024 Jun 25. Nat Struct Mol Biol. 2024. PMID: 38918639 Free PMC article.
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy.
Saunders TL, Windley SP, Gervinskas G, Balka KR, Rowe C, Lane R, Tailler M, Nguyen TN, Ramm G, Lazarou M, De Nardo D, Kile BT, McArthur K. Saunders TL, et al. Among authors: lazarou m. Cell Death Differ. 2024 Mar;31(3):335-347. doi: 10.1038/s41418-024-01260-2. Epub 2024 Feb 23. Cell Death Differ. 2024. PMID: 38396150 Free PMC article.
Interaction of PINK1 with nucleotides and kinetin.
Gan ZY, Callegari S, Nguyen TN, Kirk NS, Leis A, Lazarou M, Dewson G, Komander D. Gan ZY, et al. Among authors: lazarou m. Sci Adv. 2024 Jan 19;10(3):eadj7408. doi: 10.1126/sciadv.adj7408. Epub 2024 Jan 19. Sci Adv. 2024. PMID: 38241364 Free PMC article.
92 results