Taylor P - Search Results

1

Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques.

Rosenberg YJ, Wang J, Ooms T, Rajendran N, Mao L, Jiang X, Lees J, Urban L, Momper JD, Sepulveda Y, Shyong YJ, Taylor P. Rosenberg YJ, et al. Among authors: taylor p. Toxicol Lett. 2018 Sep 1;293:229-234. doi: 10.1016/j.toxlet.2017.10.025. Epub 2017 Nov 9. Toxicol Lett. 2018. PMID: 29129799 Free PMC article.

2

Structural bases for the specificity of cholinesterase catalysis and inhibition.

Taylor P, Radic Z, Hosea NA, Camp S, Marchot P, Berman HA. Taylor P, et al. Toxicol Lett. 1995 Dec;82-83:453-8. doi: 10.1016/0378-4274(95)03575-3. Toxicol Lett. 1995. PMID: 8597093 Review.

3

Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates.

Kovarik Z, Radić Z, Berman HA, Taylor P. Kovarik Z, et al. Among authors: taylor p. Toxicology. 2007 Apr 20;233(1-3):79-84. doi: 10.1016/j.tox.2006.08.032. Epub 2006 Sep 1. Toxicology. 2007. PMID: 17046138

4

Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.

Taylor P, Kovarik Z, Reiner E, Radić Z. Taylor P, et al. Toxicology. 2007 Apr 20;233(1-3):70-8. doi: 10.1016/j.tox.2006.11.061. Epub 2006 Nov 24. Toxicology. 2007. PMID: 17196318 Free PMC article.

5

Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation.

Küçükkilinç T, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radić Z, Taylor P. Küçükkilinç T, et al. Among authors: taylor p. Chem Biol Interact. 2010 Sep 6;187(1-3):238-40. doi: 10.1016/j.cbi.2010.03.050. Epub 2010 Apr 9. Chem Biol Interact. 2010. PMID: 20382137 Free PMC article.

6

New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Sit RK, Radić Z, Gerardi V, Zhang L, Garcia E, Katalinić M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. Sit RK, et al. Among authors: taylor p. J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4. J Biol Chem. 2011. PMID: 21464125 Free PMC article.

7

Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Radić Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Fokin VV, Sharpless KB, Taylor P. Radić Z, et al. Among authors: taylor p. J Biol Chem. 2012 Apr 6;287(15):11798-809. doi: 10.1074/jbc.M111.333732. Epub 2012 Feb 16. J Biol Chem. 2012. PMID: 22343626 Free PMC article.

8

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P. Radić Z, et al. Among authors: taylor p. Chem Biol Interact. 2013 Mar 25;203(1):67-71. doi: 10.1016/j.cbi.2012.08.014. Epub 2012 Sep 4. Chem Biol Interact. 2013. PMID: 22975155 Free PMC article.

9

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P. Radić Z, et al. Among authors: taylor p. Biochem J. 2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612. Biochem J. 2013. PMID: 23216060 Free PMC article.

10

Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system.

Schmidt HR, Radić Z, Taylor P, Fradinger EA. Schmidt HR, et al. Among authors: taylor p. Toxicol Appl Pharmacol. 2015 Apr 15;284(2):197-203. doi: 10.1016/j.taap.2015.02.011. Epub 2015 Feb 17. Toxicol Appl Pharmacol. 2015. PMID: 25701203

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