Ehrnhoefer DE - Search Results

1

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.

Ehrnhoefer DE, Southwell AL, Sivasubramanian M, Qiu X, Villanueva EB, Xie Y, Waltl S, Anderson L, Fazeli A, Casal L, Felczak B, Tsang M, Hayden MR. Ehrnhoefer DE, et al. Hum Mol Genet. 2018 Jan 15;27(2):239-253. doi: 10.1093/hmg/ddx394. Hum Mol Genet. 2018. PMID: 29121340 Free PMC article.

2

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.

Pouladi MA, Xie Y, Skotte NH, Ehrnhoefer DE, Graham RK, Kim JE, Bissada N, Yang XW, Paganetti P, Friedlander RM, Leavitt BR, Hayden MR. Pouladi MA, et al. Among authors: ehrnhoefer de. Hum Mol Genet. 2010 Apr 15;19(8):1528-38. doi: 10.1093/hmg/ddq026. Epub 2010 Jan 22. Hum Mol Genet. 2010. PMID: 20097678 Free PMC article.

3

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.

Ehrnhoefer DE, Skotte NH, Ladha S, Nguyen YT, Qiu X, Deng Y, Huynh KT, Engemann S, Nielsen SM, Becanovic K, Leavitt BR, Hasholt L, Hayden MR. Ehrnhoefer DE, et al. Hum Mol Genet. 2014 Feb 1;23(3):717-29. doi: 10.1093/hmg/ddt458. Epub 2013 Sep 18. Hum Mol Genet. 2014. PMID: 24070868

4

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH. Rotblat B, et al. Among authors: ehrnhoefer de. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516159 Free PMC article.

5

Autophagy in Huntington disease and huntingtin in autophagy.

Martin DD, Ladha S, Ehrnhoefer DE, Hayden MR. Martin DD, et al. Among authors: ehrnhoefer de. Trends Neurosci. 2015 Jan;38(1):26-35. doi: 10.1016/j.tins.2014.09.003. Epub 2014 Oct 2. Trends Neurosci. 2015. PMID: 25282404 Review.

6

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.

Aharony I, Ehrnhoefer DE, Shruster A, Qiu X, Franciosi S, Hayden MR, Offen D. Aharony I, et al. Among authors: ehrnhoefer de. Hum Mol Genet. 2015 May 1;24(9):2604-14. doi: 10.1093/hmg/ddv023. Epub 2015 Jan 23. Hum Mol Genet. 2015. PMID: 25616965 Free PMC article.

7

Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.

Graham RK, Deng Y, Pouladi MA, Vaid K, Ehrnhoefer D, Southwell AL, Bissada N, Franciosi S, Hayden MR. Graham RK, et al. J Huntingtons Dis. 2012;1(2):243-60. doi: 10.3233/JHD-120038. J Huntingtons Dis. 2012. PMID: 25063333

8

Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.

Ehrnhoefer DE, Sutton L, Hayden MR. Ehrnhoefer DE, et al. Neuroscientist. 2011 Oct;17(5):475-92. doi: 10.1177/1073858410390378. Epub 2011 Feb 10. Neuroscientist. 2011. PMID: 21311053 Free PMC article. Review.

9

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.

Carroll JB, Southwell AL, Graham RK, Lerch JP, Ehrnhoefer DE, Cao LP, Zhang WN, Deng Y, Bissada N, Henkelman RM, Hayden MR. Carroll JB, et al. Among authors: ehrnhoefer de. Mol Neurodegener. 2011 Aug 19;6:59. doi: 10.1186/1750-1326-6-59. Mol Neurodegener. 2011. PMID: 21854568 Free PMC article.

10

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.

Ehrnhoefer DE, Wong BK, Hayden MR. Ehrnhoefer DE, et al. Nat Rev Drug Discov. 2011 Oct 21;10(11):853-67. doi: 10.1038/nrd3556. Nat Rev Drug Discov. 2011. PMID: 22015920 Free PMC article. Review.

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