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RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.
Rao S, Sigl V, Wimmer RA, Novatchkova M, Jais A, Wagner G, Handschuh S, Uribesalgo I, Hagelkruys A, Kozieradzki I, Tortola L, Nitsch R, Cronin SJ, Orthofer M, Branstetter D, Canon J, Rossi J, D'Arcangelo M, Botling J, Micke P, Fleur L, Edlund K, Bergqvist M, Ekman S, Lendl T, Popper H, Takayanagi H, Kenner L, Hirsch FR, Dougall W, Penninger JM. Rao S, et al. Among authors: dougall w. Genes Dev. 2017 Oct 15;31(20):2099-2112. doi: 10.1101/gad.304162.117. Epub 2017 Nov 8. Genes Dev. 2017. PMID: 29118048 Free PMC article.
RANK is essential for osteoclast and lymph node development.
Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J. Dougall WC, et al. Genes Dev. 1999 Sep 15;13(18):2412-24. doi: 10.1101/gad.13.18.2412. Genes Dev. 1999. PMID: 10500098 Free PMC article.
RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini.
Gonzalez-Suarez E, Branstetter D, Armstrong A, Dinh H, Blumberg H, Dougall WC. Gonzalez-Suarez E, et al. Mol Cell Biol. 2007 Feb;27(4):1442-54. doi: 10.1128/MCB.01298-06. Epub 2006 Dec 4. Mol Cell Biol. 2007. PMID: 17145767 Free PMC article.
RANKL signaling in bone physiology and cancer.
Dougall WC. Dougall WC. Curr Opin Support Palliat Care. 2007 Dec;1(4):317-22. doi: 10.1097/SPC.0b013e3282f335be. Curr Opin Support Palliat Care. 2007. PMID: 18685382 Review.
95 results