Weng CC - Search Results

1

Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation.

Hou C, Hsieh CJ, Li S, Lee H, Graham TJ, Xu K, Weng CC, Doot RK, Chu W, Chakraborty SK, Dugan LL, Mintun MA, Mach RH. Hou C, et al. Among authors: weng cc. ACS Chem Neurosci. 2018 Mar 21;9(3):578-586. doi: 10.1021/acschemneuro.7b00385. Epub 2017 Dec 3. ACS Chem Neurosci. 2018. PMID: 29099578 Free PMC article.

2

Bacterial infection imaging with [¹⁸F]fluoropropyl-trimethoprim.

Sellmyer MA, Lee I, Hou C, Weng CC, Li S, Lieberman BP, Zeng C, Mankoff DA, Mach RH. Sellmyer MA, et al. Among authors: weng cc. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8372-8377. doi: 10.1073/pnas.1703109114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716936 Free PMC article.

3

Highly Selective Dopamine D₃ Receptor Antagonists with Arylated Diazaspiro Alkane Cores.

Reilly SW, Griffin S, Taylor M, Sahlholm K, Weng CC, Xu K, Jacome DA, Luedtke RR, Mach RH. Reilly SW, et al. Among authors: weng cc. J Med Chem. 2017 Dec 14;60(23):9905-9910. doi: 10.1021/acs.jmedchem.7b01248. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29125762 Free PMC article.

4

A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL. Makvandi M, et al. Among authors: weng cc. J Clin Invest. 2018 May 1;128(5):2116-2126. doi: 10.1172/JCI97992. Epub 2018 Apr 16. J Clin Invest. 2018. PMID: 29509546 Free PMC article. Clinical Trial.

5

Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity.

Reilly SW, Puentes LN, Wilson K, Hsieh CJ, Weng CC, Makvandi M, Mach RH. Reilly SW, et al. Among authors: weng cc. J Med Chem. 2018 Jun 28;61(12):5367-5379. doi: 10.1021/acs.jmedchem.8b00576. Epub 2018 Jun 14. J Med Chem. 2018. PMID: 29856625 Free PMC article.

6

Synthesis and evaluation of an AZD2461 [¹⁸F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.

Reilly SW, Puentes LN, Schmitz A, Hsieh CJ, Weng CC, Hou C, Li S, Kuo YM, Padakanti P, Lee H, Riad AA, Makvandi M, Mach RH. Reilly SW, et al. Among authors: weng cc. Bioorg Chem. 2019 Mar;83:242-249. doi: 10.1016/j.bioorg.2018.10.015. Epub 2018 Oct 17. Bioorg Chem. 2019. PMID: 30390553 Free PMC article.

7

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex.

Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH. Riad A, et al. Among authors: weng cc. Sci Rep. 2018 Nov 15;8(1):16845. doi: 10.1038/s41598-018-35430-3. Sci Rep. 2018. PMID: 30443021 Free PMC article.

8

Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [¹⁸F]FLT and [¹⁸F]ISO-1 PET/CT.

Elmi A, Makvandi M, Weng CC, Hou C, Clark AS, Mach RH, Mankoff DA. Elmi A, et al. Among authors: weng cc. Clin Cancer Res. 2019 May 15;25(10):3063-3073. doi: 10.1158/1078-0432.CCR-18-2769. Epub 2019 Jan 28. Clin Cancer Res. 2019. PMID: 30692100 Free PMC article.

9

TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death.

Zeng C, Weng CC, Schneider ME Jr, Puentes L, Riad A, Xu K, Makvandi M, Jin L, Hawkins WG, Mach RH. Zeng C, et al. Among authors: weng cc. Cell Death Discov. 2019 Jan 28;5:58. doi: 10.1038/s41420-019-0141-2. eCollection 2019. Cell Death Discov. 2019. PMID: 30701090 Free PMC article.

10

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D₃ Receptor (D₃R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs).

Reilly SW, Riad AA, Hsieh CJ, Sahlholm K, Jacome DA, Griffin S, Taylor M, Weng CC, Xu K, Kirschner N, Luedtke RR, Parry C, Malhotra S, Karanicolas J, Mach RH. Reilly SW, et al. Among authors: weng cc. J Med Chem. 2019 May 23;62(10):5132-5147. doi: 10.1021/acs.jmedchem.9b00412. Epub 2019 May 6. J Med Chem. 2019. PMID: 31021617

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