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Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.
Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Sula Karreci E, et al. Among authors: ghobrial i. JCI Insight. 2017 Nov 2;2(21):e91599. doi: 10.1172/jci.insight.91599. JCI Insight. 2017. PMID: 29093262 Free PMC article.
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.
Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, Barrat FJ, Nathan CF, Lin G, Azzi J. Sula Karreci E, et al. Among authors: ghobrial i. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8425-E8432. doi: 10.1073/pnas.1618548114. Epub 2016 Dec 12. Proc Natl Acad Sci U S A. 2016. PMID: 27956634 Free PMC article.
Multiple Myeloma and the Immune Microenvironment.
Kawano Y, Roccaro AM, Ghobrial IM, Azzi J. Kawano Y, et al. Curr Cancer Drug Targets. 2017;17(9):806-818. doi: 10.2174/1568009617666170214102301. Curr Cancer Drug Targets. 2017. PMID: 28201978 Review.
Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression.
Kawano Y, Zavidij O, Park J, Moschetta M, Kokubun K, Mouhieddine TH, Manier S, Mishima Y, Murakami N, Bustoros M, Pistofidis RS, Reidy M, Shen YJ, Rahmat M, Lukyanchykov P, Karreci ES, Tsukamoto S, Shi J, Takagi S, Huynh D, Sacco A, Tai YT, Chesi M, Bergsagel PL, Roccaro AM, Azzi J, Ghobrial IM. Kawano Y, et al. J Clin Invest. 2018 Jun 1;128(6):2487-2499. doi: 10.1172/JCI88169. Epub 2018 May 14. J Clin Invest. 2018. PMID: 29558366 Free PMC article.
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma.
Zavidij O, Haradhvala NJ, Mouhieddine TH, Sklavenitis-Pistofidis R, Cai S, Reidy M, Rahmat M, Flaifel A, Ferland B, Su NK, Agius MP, Park J, Manier S, Bustoros M, Huynh D, Capelletti M, Berrios B, Liu CJ, He MX, Braggio E, Fonseca R, Maruvka YE, Guerriero JL, Goldman M, Van Allen EM, McCarroll SA, Azzi J, Getz G, Ghobrial IM. Zavidij O, et al. Nat Cancer. 2020 May;1(5):493-506. doi: 10.1038/s43018-020-0053-3. Epub 2020 Apr 27. Nat Cancer. 2020. PMID: 33409501 Free PMC article.
The role of miRNAs in plasma cell dyscrasias.
Glavey S, Manier S, Sacco A, Rossi G, Ghobrial IM, Roccaro AM. Glavey S, et al. Microrna. 2014;2(3):165-73. doi: 10.2174/2211536602666131126002144. Microrna. 2014. PMID: 25069440 Review.
Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1.
Bar-Natan M, Stroopinsky D, Luptakova K, Coll MD, Apel A, Rajabi H, Pyzer AR, Palmer K, Reagan MR, Nahas MR, Karp Leaf R, Jain S, Arnason J, Ghobrial IM, Anderson KC, Kufe D, Rosenblatt J, Avigan D. Bar-Natan M, et al. Br J Haematol. 2017 Mar;176(6):929-938. doi: 10.1111/bjh.14493. Epub 2017 Jan 20. Br J Haematol. 2017. PMID: 28107546 Free PMC article.
401 results