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Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities.
Unterhauser K, Pöltl L, Schneditz G, Kienesberger S, Glabonjat RA, Kitsera M, Pletz J, Josa-Prado F, Dornisch E, Lembacher-Fadum C, Roier S, Gorkiewicz G, Lucena D, Barasoain I, Kroutil W, Wiedner M, Loizou JI, Breinbauer R, Díaz JF, Schild S, Högenauer C, Zechner EL. Unterhauser K, et al. Among authors: poltl l. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi: 10.1073/pnas.1819154116. Epub 2019 Feb 11. Proc Natl Acad Sci U S A. 2019. PMID: 30808763 Free PMC article.
Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity.
Ledala N, Malik M, Rezaul K, Paveglio S, Provatas A, Kiel A, Caimano M, Zhou Y, Lindgren J, Krasulova K, Illes P, Dvořák Z, Kortagere S, Kienesberger S, Cosic A, Pöltl L, Zechner EL, Ghosh S, Mani S, Radolf JD, Matson AP. Ledala N, et al. Among authors: poltl l. mBio. 2022 Feb 22;13(1):e0375221. doi: 10.1128/mbio.03752-21. Epub 2022 Jan 25. mBio. 2022. PMID: 35073747 Free PMC article.
Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations.
Pöltl L, Kitsera M, Raffl S, Schild S, Cosic A, Kienesberger S, Unterhauser K, Raber G, Lembacher-Fadum C, Breinbauer R, Gorkiewicz G, Sebastian C, Hoefler G, Zechner EL. Pöltl L, et al. Cell Rep. 2023 Mar 28;42(3):112199. doi: 10.1016/j.celrep.2023.112199. Epub 2023 Mar 3. Cell Rep. 2023. PMID: 36870054 Free article.