Wu H - Search Results

1

Can small molecule inhibitors of glutaminyl cyclase be used as a therapeutic for Alzheimer's disease?

Wu H. Wu H. Future Med Chem. 2017 Nov;9(17):1979-1981. doi: 10.4155/fmc-2017-0190. Epub 2017 Oct 27. Future Med Chem. 2017. PMID: 29076753

2

Inhibitory effect of flavonoids on human glutaminyl cyclase.

Li M, Dong Y, Yu X, Zou Y, Zheng Y, Bu X, Quan J, He Z, Wu H. Li M, et al. Among authors: wu h. Bioorg Med Chem. 2016 May 15;24(10):2280-6. doi: 10.1016/j.bmc.2016.03.064. Epub 2016 Apr 1. Bioorg Med Chem. 2016. PMID: 27061673

3

Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease.

Li M, Dong Y, Yu X, Li Y, Zou Y, Zheng Y, He Z, Liu Z, Quan J, Bu X, Wu H. Li M, et al. Among authors: wu h. J Med Chem. 2017 Aug 10;60(15):6664-6677. doi: 10.1021/acs.jmedchem.7b00648. Epub 2017 Jul 25. J Med Chem. 2017. PMID: 28700245

4

Glutaminyl cyclase inhibitor contributes to the regulation of HSP70, HSP90, actin, and ribosome on gene and protein levels in vitro.

Yu X, Li Y, Zou Y, Zheng Y, He Z, Liu Z, Xie W, Wu H. Yu X, et al. Among authors: wu h. J Cell Biochem. 2019 Jun;120(6):9460-9471. doi: 10.1002/jcb.28222. Epub 2018 Dec 23. J Cell Biochem. 2019. PMID: 30582198

5

Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice.

Wang X, Wang L, Yu X, Li Y, Liu Z, Zou Y, Zheng Y, He Z, Wu H. Wang X, et al. Among authors: wu h. Int Immunopharmacol. 2019 Oct;75:105770. doi: 10.1016/j.intimp.2019.105770. Epub 2019 Aug 1. Int Immunopharmacol. 2019. PMID: 31377588

6

Repurposing FDA-Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease.

Xu C, Zou H, Yu X, Xie Y, Cai J, Shang Q, Ouyang N, Wang Y, Xu P, He Z, Wu H. Xu C, et al. Among authors: wu h. ChemistryOpen. 2021 Sep;10(9):877-881. doi: 10.1002/open.202000235. Epub 2020 Dec 30. ChemistryOpen. 2021. PMID: 33377311 Free PMC article.

7

Glutaminyl Cyclase, Diseases, and Development of Glutaminyl Cyclase Inhibitors.

Xu C, Wang YN, Wu H. Xu C, et al. Among authors: wu h. J Med Chem. 2021 May 27;64(10):6549-6565. doi: 10.1021/acs.jmedchem.1c00325. Epub 2021 May 17. J Med Chem. 2021. PMID: 34000808 Review.

8

Upregulation of Glutaminyl Cyclase Contributes to ERS-Induced Apoptosis in PC12 Cells.

Shang Q, Yu X, Ouyang N, Xu P, Chen X, Wang Y, Li C, Wang X, Lu X, Xu C, Wu H. Shang Q, et al. Among authors: wu h. Biomed Res Int. 2022 Nov 28;2022:4154697. doi: 10.1155/2022/4154697. eCollection 2022. Biomed Res Int. 2022. PMID: 36479306 Free PMC article.

9

Design, synthesis and anti-AD effects of dual inhibitor targeting glutaminyl cyclase/GSK-3β.

Xie Y, Chen C, Lin S, Yu X, Ye S, Chen X, Ouyang N, Xiong W, Li C, Xu C, Song G, Wu H. Xie Y, et al. Among authors: wu h. Eur J Med Chem. 2023 Feb 15;248:115089. doi: 10.1016/j.ejmech.2023.115089. Epub 2023 Jan 6. Eur J Med Chem. 2023. PMID: 36638710

10

Discovery of potential scaffolds for glutaminyl cyclase inhibitors: Virtual screening, synthesis, and evaluation.

Zhou Q, Cai J, Qin F, Liu J, Li C, Xiong W, Wang Y, Xu C, Wu H. Zhou Q, et al. Among authors: wu h. Bioorg Med Chem. 2024 Jan 1;97:117542. doi: 10.1016/j.bmc.2023.117542. Epub 2023 Dec 6. Bioorg Med Chem. 2024. PMID: 38104495

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