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Page 1
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.
Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR. Michelakis ED, et al. Among authors: boukouris ae. Sci Transl Med. 2017 Oct 25;9(413):eaao4583. doi: 10.1126/scitranslmed.aao4583. Sci Transl Med. 2017. PMID: 29070699 Free article. Clinical Trial.
Interaction with p53 explains a pro-proliferative function for VHL in cancer.
Kinnaird A, Boukouris AE, Saleme B, Dromparis P, Zervopoulos SD, Gurtu V, Sutendra G, Michelakis ED. Kinnaird A, et al. Among authors: boukouris ae. J Mol Med (Berl). 2020 Sep;98(9):1269-1278. doi: 10.1007/s00109-020-01951-6. Epub 2020 Jul 28. J Mol Med (Berl). 2020. PMID: 32725274
p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology.
Saleme B, Das SK, Zhang Y, Boukouris AE, Lorenzana Carrillo MA, Jovel J, Wagg CS, Lopaschuk GD, Michelakis ED, Sutendra G. Saleme B, et al. Among authors: boukouris ae. J Am Heart Assoc. 2020 Aug 4;9(15):e017247. doi: 10.1161/JAHA.120.017247. Epub 2020 Jul 29. J Am Heart Assoc. 2020. PMID: 32750288 Free PMC article. No abstract available.
SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.
Zhang Y, Zervopoulos SD, Boukouris AE, Lorenzana-Carrillo MA, Saleme B, Webster L, Liu Y, Haromy A, Tabatabaei Dakhili SA, Ussher JR, Sutendra G, Michelakis ED. Zhang Y, et al. Among authors: boukouris ae. J Am Heart Assoc. 2021 Dec 7;10(23):e020451. doi: 10.1161/JAHA.120.020451. Epub 2021 Oct 30. J Am Heart Assoc. 2021. PMID: 34719264 Free PMC article.
A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.
Boukouris AE, Zhang Y, Saleme B, Kinnaird A, Zhao YY, Liu Y, Zervopoulos SD, Das SK, Mittal RD, Haromy A, Lorenzana-Carrillo MA, Krysler AR, Cromwell CR, Hubbard BP, Sutendra G, Michelakis ED. Boukouris AE, et al. Cell Rep. 2022 Mar 15;38(11):110511. doi: 10.1016/j.celrep.2022.110511. Cell Rep. 2022. PMID: 35294884 Free article.
Loss of the fructose transporter SLC2A5 inhibits cancer cell migration.
Groenendyk J, Stoletov K, Paskevicius T, Li W, Dai N, Pujol M, Busaan E, Ng HH, Boukouris AE, Saleme B, Haromy A, Cui K, Hu M, Yan Y, Zhang R, Michelakis E, Chen XZ, Lewis JD, Tang J, Agellon LB, Michalak M. Groenendyk J, et al. Among authors: boukouris ae. Front Cell Dev Biol. 2022 Sep 30;10:896297. doi: 10.3389/fcell.2022.896297. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36268513 Free PMC article.
Endothelin Receptor Blocker Reverses Breast Cancer-Induced Cardiac Remodeling.
Maayah ZH, Ferdaoussi M, Boukouris AE, Takahara S, Das SK, Khairy M, Mackey JR, Pituskin E, Sutendra G, Paterson DI, Dyck JRB. Maayah ZH, et al. Among authors: boukouris ae. JACC CardioOncol. 2023 May 2;5(5):686-700. doi: 10.1016/j.jaccao.2023.02.004. eCollection 2023 Oct. JACC CardioOncol. 2023. PMID: 37969640 Free PMC article.
15 results