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In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor.
Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Lawton J, Kim N, Silverstein RA, da Silva JF, de la Cruz D, Richa R, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL. Alves CRR, et al. Among authors: chao lh. bioRxiv [Preprint]. 2024 Nov 11:2024.11.11.621817. doi: 10.1101/2024.11.11.621817. bioRxiv. 2024. PMID: 39605323 Free PMC article. Preprint.
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases.
Ferreira da Silva J, Tou CJ, King EM, Eller ML, Rufino-Ramos D, Ma L, Cromwell CR, Metovic J, Benning FMC, Chao LH, Eichler FS, Kleinstiver BP. Ferreira da Silva J, et al. Among authors: chao lh. Nat Biotechnol. 2024 Jul 22:10.1038/s41587-024-02324-x. doi: 10.1038/s41587-024-02324-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 39039307
Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2.
Boopathy S, Luce BE, Lugo CM, Hakim P, McDonald J, Kim HL, Ponce J, Ueberheide BM, Chao LH. Boopathy S, et al. Among authors: chao lh. bioRxiv [Preprint]. 2024 Jul 27:2023.12.29.573615. doi: 10.1101/2023.12.29.573615. bioRxiv. 2024. Update in: J Biol Chem. 2024 Oct;300(10):107740. doi: 10.1016/j.jbc.2024.107740 PMID: 38234813 Free PMC article. Updated. Preprint.
In situ architecture of Opa1-dependent mitochondrial cristae remodeling.
Fry MY, Navarro PP, Hakim P, Ananda VY, Qin X, Landoni JC, Rath S, Inde Z, Lugo CM, Luce BE, Ge Y, McDonald JL, Ali I, Ha LL, Kleinstiver BP, Chan DC, Sarosiek KA, Chao LH. Fry MY, et al. Among authors: chao lh. EMBO J. 2024 Feb;43(3):391-413. doi: 10.1038/s44318-024-00027-2. Epub 2024 Jan 15. EMBO J. 2024. PMID: 38225406 Free PMC article.
51 results