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Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.
Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofigari-Esfahani N, Rosanelli L, Titorenko VI. Leonov A, et al. Among authors: arlia ciommo a. Oncotarget. 2017 Sep 1;8(41):69328-69350. doi: 10.18632/oncotarget.20614. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050207 Free PMC article.
Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes.
Lutchman V, Medkour Y, Samson E, Arlia-Ciommo A, Dakik P, Cortes B, Feldman R, Mohtashami S, McAuley M, Chancharoen M, Rukundo B, Simard É, Titorenko VI. Lutchman V, et al. Among authors: arlia ciommo a. Oncotarget. 2016 Mar 29;7(13):16542-66. doi: 10.18632/oncotarget.7665. Oncotarget. 2016. PMID: 26918729 Free PMC article.
Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast.
Leonov A, Arlia-Ciommo A, Bourque SD, Koupaki O, Kyryakov P, Dakik P, McAuley M, Medkour Y, Mohammad K, Di Maulo T, Titorenko VI. Leonov A, et al. Among authors: arlia ciommo a. Oncotarget. 2017 May 9;8(19):30672-30691. doi: 10.18632/oncotarget.16766. Oncotarget. 2017. PMID: 28410198 Free PMC article.
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.
Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI. Arlia-Ciommo A, et al. Oncotarget. 2018 Mar 5;9(22):16163-16184. doi: 10.18632/oncotarget.24604. eCollection 2018 Mar 23. Oncotarget. 2018. PMID: 29662634 Free PMC article.
Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast.
Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard É, Titorenko VI. Dakik P, et al. Among authors: arlia ciommo a. Oncotarget. 2020 Jun 9;11(23):2182-2203. doi: 10.18632/oncotarget.27615. eCollection 2020 Jun 9. Oncotarget. 2020. PMID: 32577164 Free PMC article.
16 results