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The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer.
Zhang J, Liu S, Li Q, Shi Y, Wu Y, Liu F, Wang S, Zaky MY, Yousuf W, Sun Q, Guo D, Wang T, Zhang Y, Wang Y, Li M, Liu H. Zhang J, et al. Among authors: wang y, wang t, wang s. Cell Death Differ. 2020 Sep;27(9):2710-2725. doi: 10.1038/s41418-020-0538-8. Epub 2020 Apr 23. Cell Death Differ. 2020. PMID: 32327714 Free PMC article.
Dynasore-induced potent ubiquitylation of the exon 19 deletion mutant of epidermal growth factor receptor suppresses cell growth and migration in non-small cell lung cancer.
Wang T, Wang D, Zhang Y, Zhang J, Sun X, Wu Y, Wang S, Zhang Y, Xu L, Kong Q, Gao Y, Wu Y, Liu F, Liu S, Zhang Y, Lei T, Liu H. Wang T, et al. Among authors: wang d, wang s. Int J Biochem Cell Biol. 2018 Dec;105:1-12. doi: 10.1016/j.biocel.2018.09.017. Epub 2018 Sep 28. Int J Biochem Cell Biol. 2018. PMID: 30268747
Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer.
Zhang J, Li Q, Wu Y, Wang D, Xu L, Zhang Y, Wang S, Wang T, Liu F, Zaky MY, Hou S, Liu S, Zou K, Lei H, Zou L, Zhang Y, Liu H. Zhang J, et al. Among authors: wang d, wang t, wang s. Cell Commun Signal. 2019 Feb 20;17(1):15. doi: 10.1186/s12964-019-0328-4. Cell Commun Signal. 2019. PMID: 30786890 Free PMC article.
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