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Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine.
Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Dempsey DR, et al. Among authors: lewandowski em. Sci Rep. 2017 Oct 18;7(1):13432. doi: 10.1038/s41598-017-13669-6. Sci Rep. 2017. PMID: 29044148 Free PMC article.
Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target.
O'Flynn BG, Lewandowski EM, Prins KC, Suarez G, McCaskey AN, Rios-Guzman NM, Anderson RL, Shepherd BA, Gelis I, Leahy JW, Chen Y, Merkler DJ. O'Flynn BG, et al. Among authors: lewandowski em. ACS Chem Biol. 2020 Feb 21;15(2):513-523. doi: 10.1021/acschembio.9b00973. Epub 2020 Feb 3. ACS Chem Biol. 2020. PMID: 31967772
Low barrier hydrogen bonds in protein structure and function.
Kemp MT, Lewandowski EM, Chen Y. Kemp MT, et al. Among authors: lewandowski em. Biochim Biophys Acta Proteins Proteom. 2021 Jan;1869(1):140557. doi: 10.1016/j.bbapap.2020.140557. Epub 2020 Oct 23. Biochim Biophys Acta Proteins Proteom. 2021. PMID: 33148530 Free PMC article. Review.
Structural Insights into Molecular Recognition by Human Chemokine CCL19.
Lewandowski EM, Kroeck KG, Jacobs LMC, Fenske TG, Witt RN, Hintz AM, Ramsden ER, Zhang X, Peterson F, Volkman BF, Veldkamp CT, Chen Y. Lewandowski EM, et al. Biochemistry. 2022 Mar 1;61(5):311-318. doi: 10.1021/acs.biochem.1c00759. Epub 2022 Feb 14. Biochemistry. 2022. PMID: 35156805 Free PMC article.
A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations.
Ou J, Lewandowski EM, Hu Y, Lipinski AA, Morgan RT, Jacobs LMC, Zhang X, Bikowitz MJ, Langlais P, Tan H, Wang J, Chen Y, Choy JS. Ou J, et al. Among authors: lewandowski em. bioRxiv [Preprint]. 2022 Aug 8:2022.08.06.503039. doi: 10.1101/2022.08.06.503039. bioRxiv. 2022. Update in: PLoS Pathog. 2023 Aug 31;19(8):e1011592. doi: 10.1371/journal.ppat.1011592 PMID: 35982672 Free PMC article. Updated. Preprint.
A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations.
Ou J, Lewandowski EM, Hu Y, Lipinski AA, Morgan RT, Jacobs LMC, Zhang X, Bikowitz MJ, Langlais P, Tan H, Wang J, Chen Y, Choy JS. Ou J, et al. Among authors: lewandowski em. Res Sq [Preprint]. 2022 Aug 26:rs.3.rs-1942964. doi: 10.21203/rs.3.rs-1942964/v1. Res Sq. 2022. Update in: PLoS Pathog. 2023 Aug 31;19(8):e1011592. doi: 10.1371/journal.ppat.1011592 PMID: 36052369 Free PMC article. Updated. Preprint.
Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir.
Hu Y, Lewandowski EM, Tan H, Zhang X, Morgan RT, Zhang X, Jacobs LMC, Butler SG, Gongora MV, Choy J, Deng X, Chen Y, Wang J. Hu Y, et al. Among authors: lewandowski em. bioRxiv [Preprint]. 2022 Sep 6:2022.06.28.497978. doi: 10.1101/2022.06.28.497978. bioRxiv. 2022. Update in: ACS Cent Sci. 2023 Jul 24;9(8):1658-1669. doi: 10.1021/acscentsci.3c00538 PMID: 36119652 Free PMC article. Updated. Preprint.
20 results