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Page 1
The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.
Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ. Meijles DN, et al. Among authors: knupp he. Sci Signal. 2017 Oct 17;10(501):eaaj1784. doi: 10.1126/scisignal.aaj1784. Sci Signal. 2017. PMID: 29042481 Free PMC article.
TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.
Rogers NM, Sharifi-Sanjani M, Yao M, Ghimire K, Bienes-Martinez R, Mutchler SM, Knupp HE, Baust J, Novelli EM, Ross M, St Croix C, Kutten JC, Czajka CA, Sembrat JC, Rojas M, Labrousse-Arias D, Bachman TN, Vanderpool RR, Zuckerbraun BS, Champion HC, Mora AL, Straub AC, Bilonick RA, Calzada MJ, Isenberg JS. Rogers NM, et al. Among authors: knupp he. Cardiovasc Res. 2017 Jan;113(1):15-29. doi: 10.1093/cvr/cvw218. Epub 2016 Oct 13. Cardiovasc Res. 2017. PMID: 27742621 Free PMC article.
Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.
Novelli EM, Little-Ihrig L, Knupp HE, Rogers NM, Yao M, Baust JJ, Meijles D, St Croix CM, Ross MA, Pagano PJ, DeVallance ER, Miles G, Potoka KP, Isenberg JS, Gladwin MT. Novelli EM, et al. Among authors: knupp he. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1150-L1164. doi: 10.1152/ajplung.00302.2018. Epub 2019 Mar 20. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30892078 Free PMC article.
Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension.
Rogers NM, Yao M, Sembrat J, George MP, Knupp H, Ross M, Sharifi-Sanjani M, Milosevic J, St Croix C, Rajkumar R, Frid MG, Hunter KS, Mazzaro L, Novelli EM, Stenmark KR, Gladwin MT, Ahmad F, Champion HC, Isenberg JS. Rogers NM, et al. Pulm Circ. 2013 Dec;3(4):936-51. doi: 10.1086/674754. Pulm Circ. 2013. PMID: 25006410 Free PMC article.