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The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.
Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ. Meijles DN, et al. Among authors: isenberg js. Sci Signal. 2017 Oct 17;10(501):eaaj1784. doi: 10.1126/scisignal.aaj1784. Sci Signal. 2017. PMID: 29042481 Free PMC article.
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.
Bauer PM, Bauer EM, Rogers NM, Yao M, Feijoo-Cuaresma M, Pilewski JM, Champion HC, Zuckerbraun BS, Calzada MJ, Isenberg JS. Bauer PM, et al. Among authors: isenberg js. Cardiovasc Res. 2012 Mar 15;93(4):682-93. doi: 10.1093/cvr/cvr356. Epub 2012 Jan 2. Cardiovasc Res. 2012. PMID: 22215724 Free PMC article.
Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates.
Novelli EM, Kato GJ, Ragni MV, Zhang Y, Hildesheim ME, Nouraie M, Barge S, Meyer MP, Hassett AC, Gordeuk VR, Gladwin MT, Isenberg JS. Novelli EM, et al. Among authors: isenberg js. Am J Hematol. 2012 Mar;87(3):326-30. doi: 10.1002/ajh.22274. Epub 2012 Feb 8. Am J Hematol. 2012. PMID: 22318901 Free PMC article.
Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1.
Csányi G, Yao M, Rodríguez AI, Al Ghouleh I, Sharifi-Sanjani M, Frazziano G, Huang X, Kelley EE, Isenberg JS, Pagano PJ. Csányi G, et al. Among authors: isenberg js. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2966-73. doi: 10.1161/ATVBAHA.112.300031. Epub 2012 Oct 18. Arterioscler Thromb Vasc Biol. 2012. PMID: 23087362 Free PMC article.
Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease.
Novelli EM, Kato GJ, Hildesheim ME, Barge S, Meyer MP, Lozier J, Hassett AC, Ragni MV, Isenberg JS, Gladwin MT. Novelli EM, et al. Among authors: isenberg js. Haematologica. 2013 Nov;98(11):e132-4. doi: 10.3324/haematol.2013.092635. Haematologica. 2013. PMID: 24186313 Free PMC article. No abstract available.
189 results