Ching KH - Search Results

1

Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets.

Ching KH, Collarini EJ, Abdiche YN, Bedinger D, Pedersen D, Izquierdo S, Harriman R, Zhu L, Etches RJ, van de Lavoir MC, Harriman WD, Leighton PA. Ching KH, et al. MAbs. 2018 Jan;10(1):71-80. doi: 10.1080/19420862.2017.1386825. Epub 2017 Nov 2. MAbs. 2018. PMID: 29035625 Free PMC article.

2

Generation of chickens expressing Cre recombinase.

Leighton PA, Pedersen D, Ching K, Collarini EJ, Izquierdo S, Jacob R, van de Lavoir MC. Leighton PA, et al. Transgenic Res. 2016 Oct;25(5):609-16. doi: 10.1007/s11248-016-9952-6. Epub 2016 Mar 31. Transgenic Res. 2016. PMID: 27034267 Free PMC article.

3

Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells.

Dimitrov L, Pedersen D, Ching KH, Yi H, Collarini EJ, Izquierdo S, van de Lavoir MC, Leighton PA. Dimitrov L, et al. Among authors: ching kh. PLoS One. 2016 Apr 21;11(4):e0154303. doi: 10.1371/journal.pone.0154303. eCollection 2016. PLoS One. 2016. PMID: 27099923 Free PMC article.

4

Expression of heavy chain-only antibodies can support B-cell development in light chain knockout chickens.

Schusser B, Collarini EJ, Pedersen D, Yi H, Ching K, Izquierdo S, Thoma T, Lettmann S, Kaspers B, Etches RJ, van de Lavoir MC, Harriman W, Leighton PA. Schusser B, et al. Eur J Immunol. 2016 Sep;46(9):2137-48. doi: 10.1002/eji.201546171. Epub 2016 Aug 2. Eur J Immunol. 2016. PMID: 27392810 Free PMC article.

5

V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species.

Leighton PA, Morales J, Harriman WD, Ching KH. Leighton PA, et al. Among authors: ching kh. Front Immunol. 2018 Jun 11;9:1317. doi: 10.3389/fimmu.2018.01317. eCollection 2018. Front Immunol. 2018. PMID: 29951062 Free PMC article.

6

Expression of human lambda expands the repertoire of OmniChickens.

Ching KH, Berg K, Morales J, Pedersen D, Harriman WD, Abdiche YN, Leighton PA. Ching KH, et al. PLoS One. 2020 Jan 29;15(1):e0228164. doi: 10.1371/journal.pone.0228164. eCollection 2020. PLoS One. 2020. PMID: 31995598 Free PMC article.

7

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms.

Cameron B, Dabdoubi T, Berthou-Soulié L, Gagnaire M, Arnould I, Severac A, Soubrier F, Morales J, Leighton PA, Harriman W, Ching K, Abdiche Y, Radošević K, Bouquin T. Cameron B, et al. PLoS One. 2020 Jul 16;15(7):e0235815. doi: 10.1371/journal.pone.0235815. eCollection 2020. PLoS One. 2020. PMID: 32673351 Free PMC article.

8

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics.

Ching KH, Berg K, Reynolds K, Pedersen D, Macias A, Abdiche YN, Harriman WD, Leighton PA. Ching KH, et al. MAbs. 2021 Jan-Dec;13(1):1862451. doi: 10.1080/19420862.2020.1862451. MAbs. 2021. PMID: 33491549 Free PMC article.

9

Chickens with a Truncated Light Chain Transgene Express Single-Domain H Chain-Only Antibodies.

Leighton PA, Ching K, Reynolds K, Vuong CN, Zeng B, Zhang Y, Gupta A, Morales J, Rivera GS, Srivastava DB, Cotter R, Pedersen D, Collarini E, Izquierdo S, van de Lavoir MC, Harriman W. Leighton PA, et al. J Immunol. 2024 Jun 1;212(11):1744-1753. doi: 10.4049/jimmunol.2300617. J Immunol. 2024. PMID: 38629917 Free PMC article.

10

Lateral Flow Immunoassay.

Ching KH. Ching KH. Methods Mol Biol. 2015;1318:127-37. doi: 10.1007/978-1-4939-2742-5_13. Methods Mol Biol. 2015. PMID: 26160571

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