Chiosis G - Search Results

1

Proteomic interrogation of HSP90 and insights for medical research.

Weidenauer L, Wang T, Joshi S, Chiosis G, Quadroni MR. Weidenauer L, et al. Among authors: chiosis g. Expert Rev Proteomics. 2017 Dec;14(12):1105-1117. doi: 10.1080/14789450.2017.1389649. Epub 2017 Oct 16. Expert Rev Proteomics. 2017. PMID: 28990809 Free PMC article. Review.

2

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.

Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp-Lorenzino L, Rosen N. Chiosis G, et al. Chem Biol. 2001 Mar;8(3):289-99. doi: 10.1016/s1074-5521(01)00015-1. Chem Biol. 2001. PMID: 11306353

3

Development of purine-scaffold small molecule inhibitors of Hsp90.

Chiosis G, Lucas B, Huezo H, Solit D, Basso A, Rosen N. Chiosis G, et al. Curr Cancer Drug Targets. 2003 Oct;3(5):371-6. doi: 10.2174/1568009033481778. Curr Cancer Drug Targets. 2003. PMID: 14529388 Review.

4

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G. Llauger-Bufi L, et al. Among authors: chiosis g. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8. doi: 10.1016/j.bmcl.2003.08.065. Bioorg Med Chem Lett. 2003. PMID: 14592488

5

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G. Vilenchik M, et al. Among authors: chiosis g. Chem Biol. 2004 Jun;11(6):787-97. doi: 10.1016/j.chembiol.2004.04.008. Chem Biol. 2004. PMID: 15217612

6

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

Kim J, Felts S, Llauger L, He H, Huezo H, Rosen N, Chiosis G. Kim J, et al. Among authors: chiosis g. J Biomol Screen. 2004 Aug;9(5):375-81. doi: 10.1177/1087057104265995. J Biomol Screen. 2004. PMID: 15296636

7

Hsp90: the vulnerable chaperone.

Chiosis G, Vilenchik M, Kim J, Solit D. Chiosis G, et al. Drug Discov Today. 2004 Oct 15;9(20):881-8. doi: 10.1016/S1359-6446(04)03245-3. Drug Discov Today. 2004. PMID: 15475321 Review.

8

Targeting chaperones in transformed systems--a focus on Hsp90 and cancer.

Chiosis G. Chiosis G. Expert Opin Ther Targets. 2006 Feb;10(1):37-50. doi: 10.1517/14728222.10.1.37. Expert Opin Ther Targets. 2006. PMID: 16441227 Review.

9

Emerging Hsp90 inhibitors: from discovery to clinic.

Chiosis G, Rodina A, Moulick K. Chiosis G, et al. Anticancer Agents Med Chem. 2006 Jan;6(1):1-8. doi: 10.2174/187152006774755483. Anticancer Agents Med Chem. 2006. PMID: 16475922 Review.

10

Synthesis of Hsp90 dimerization modulators.

Chiosis G, Aguirre J, Nicchitta CV. Chiosis G, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. doi: 10.1016/j.bmcl.2006.03.092. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621545

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